1-Decanol
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| Names | |
|---|---|
| Preferred IUPAC name Decan-1-ol | |
| Other names decyl alcohol n-decyl alcohol capric alcohol epal 10 antak agent 504 | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.003.597 |
| KEGG | |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
| |
| |
| Properties | |
| C10H21OH | |
| Molar mass | 158.28 g/mol |
| Appearance | Viscous liquid |
| Density | 0.8297 g/cm3 |
| Melting point | 6.4 °C (43.5 °F; 279.5 K) |
| Boiling point | 232.9 °C (451.2 °F; 506.0 K) |
| 37 mg/L at 20°C[2] | |
| log P | 4.57 |
| Viscosity | 12.048 mPa.s (@ 25 °C) |
| Hazards | |
| Flash point | 108 °C (226 °F; 381 K) |
| Safety data sheet (SDS) | Oxford MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
1-Decanol is a straight chain fatty alcohol with ten carbon atoms and the molecular formula C10H21OH. It is a colorless to light yellow viscous liquid that is insoluble in water and has an aromatic odor.[3] The interfacial tension against water at 20 °C is 8.97 mN/m.
Production
[edit]Decanol can be prepared by the hydrogenation of decanoic acid, which occurs in modest quantities in coconut oil (about 10%) and palm kernel oil (about 4%). It may also be produced synthetically via the Ziegler process.
Uses
[edit]Decanol is used in the manufacture of plasticizers, lubricants, surfactants and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for transdermal drug delivery.[4][5]
Safety
[edit]Like other medium chain fatty alcohols, 1-decanol is able to permeate the skin which can lead to irritation.
References
[edit]- ^ Merck Index, 12th Edition, 2911.
- ^ "1-Decanol".
- ^ "Material Safety Data Sheet - Decyl alcohol, 99%". fscimage.fishersci.com. Archived from the original on 2021-09-01. Retrieved 2021-09-01.
- ^ Kanikkannan, N; Singh, Mandip (November 2002). "Skin permeation enhancement effect and skin irritation of saturated fatty alcohols". International Journal of Pharmaceutics. 248 (1–2): 219–228. doi:10.1016/S0378-5173(02)00454-4. PMID 12429475.
- ^ Williams, Adrian C; Barry, Brian W (March 2004). "Penetration enhancers". Advanced Drug Delivery Reviews. 56 (5): 603–618. doi:10.1016/j.addr.2003.10.025. PMID 15019749.
