ASB2

ASB2
Identifiers
AliasesASB2, ASB-2, ankyrin repeat and SOCS box containing 2
External IDsOMIM: 605759; MGI: 1929743; HomoloGene: 69202; GeneCards: ASB2; OMA:ASB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202429
NM_016150

NM_023049
NM_001374764

RefSeq (protein)

NP_001189358
NP_057234

NP_075536
NP_001361693

Location (UCSC)Chr 14: 93.93 – 93.98 MbChr 12: 103.29 – 103.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.[5]

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.[5]

References

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  1. ^ a b c ENSG00000278693 GRCh38: Ensembl release 89: ENSG00000100628, ENSG00000278693Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021200Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2".
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Further reading

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