Alwyn Jones (biophysicist)

Alwyn Jones
Born
Thomas Alywn Jones

(1947-08-30) 30 August 1947 (age 77)
Wales
Alma materKing's College London
Known forMethods development for X-ray crystallography, such as interpretation of electron density maps
Awards
Scientific career
FieldsStructure validation, biophysics
InstitutionsUppsala University
Thesis (BSc 1969; PhD 1973)
Websitexray.bmc.uu.se/alwyn

Thomas Alwyn Jones (born 30 August 1947) is a Welsh biophysicist and a professor at the Uppsala University in Sweden.

Early life and education

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Alwyn Jones attended the primary school at Bedlinog, and went on to the Lewis School, Pengam where he studied his GCE Ordinary Levels and A-levels. He was educated at King's College London, where he received his BSc in physics and a PhD degree in biochemistry.[1]

Career

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He held various positions at the Max Planck Institute for Biochemistry, Munich from 1973 to 1979, and in Uppsala from 1979.[2] Jones was a research professor employed by the Swedish Natural Science Research Council 1987–1994, and has been Professor of Structural Biology at the Department of Molecular Biology, Uppsala, from 1994.[1] He is also a Fellow of the Royal Society (elected in 1992) and a Foreign member of the Royal Swedish Academy of Sciences (elected in 2000).[3][4] He is a recipient of the Gregori Aminoff Prize (2003), "for his pioneering development of methods to interpret electron density maps and to build models of biological macromolecules with the aid of computer graphics" and the Lindo Patterson Award, 2005, from the American Crystallographic Association.[3][5]

Jones is most noted for development of widely used programs for fitting models into crystallographic electron density maps, first Frodo,[6] then its further developed version O (molecular graphics),[7][8] and for involvement in structure validation.[7][9] He has solved a very large number of protein crystal structures and is listed as a depositor on 126 structures at the Protein Data Bank, especially emphasizing enzymes and viruses.[10][11][12][13] Web of Science credits him with over 29,000 citations,[14] and Google Scholar with over 14,000 citations (since 1990) and an h-index of 58, including over 11,000 citations for O and 1700 for Frodo.[6][7] He is currently a professor at Uppsala University in Sweden.[15]

References

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  1. ^ a b "Curriculum vitae Thomas Alwyn Jones (130624)". Biomedical Centre, Uppsala, Sweden. Retrieved 1 May 2016.
  2. ^ "Developer Tale". SBGrid Consortium. 17 June 2011. Retrieved 1 May 2016.
  3. ^ a b "Alwyn Jones". Royal Society. Retrieved 1 May 2016.
  4. ^ "T. Alwyn Jones". Royal Swedish Academy of Sciences. Archived from the original on 1 February 2016. Retrieved 1 May 2016.
  5. ^ "T Alwyn Jones" (in Swedish). Royal Swedish Academy of Sciences. Retrieved 1 May 2016.
  6. ^ a b Jones TA (1978). "A Graphics Model Building and Refinement System for Macromolecules". Journal of Applied Crystallography. 11: 268–272. doi:10.1107/S0021889878013308.
  7. ^ a b c Jones TA, Zou J-Y, Cowan SW, Kjeldgaard M (1991). "Improved methods for the building of protein models in electron density maps and the location of errors in these models". Acta Crystallographica. A47: 110–119. doi:10.1107/s0108767390010224.
  8. ^ "O 15 Release Notes". 17 January 2018. Retrieved 21 May 2019.
  9. ^ Kleywegt GJ, Jones TA (1996). "Phi/Psi-chology: Ramachandran revisited". Structure. 4 (12): 1395–1400. doi:10.1016/S0969-2126(96)00147-5. PMID 8994966.
  10. ^ Cameron D, Olin B, Ridderström M, Mannervik B, Jones TA (1997). "Crystal structure of human glyoxalase 1 - evidence for gene duplication and 3D swapping". EMBO Journal. 16: 3386–3395. doi:10.1093/emboj/16.12.3386. PMC 1169964. PMID 9218781.
  11. ^ Zou J, Hallberg BM, Bergfors T, Oesch F, Arand M, Mowbray SL, Jones TA (2000). "Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases". Structure. 8: 111–122. doi:10.1016/s0969-2126(00)00087-3. PMID 10673439.
  12. ^ Jones TA, Liljas L (1984). "Structure of satellite tobacco necrosis virus after crystallographic refinement at 2.5 Å resolution". Journal of Molecular Biology. 177: 735–767. doi:10.1016/0022-2836(84)90047-0.
  13. ^ Jansson AM, Jakobsson E, Johansson P, Lantez V, Coutard B, de Lamballerie X, Unge T, Jones TA (2009). "Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector". Acta Crystallographica. D65: 796–803. doi:10.1107/s0907444909017260.
  14. ^ "Web of Science". Thomson Reuters. Archived from the original on 1 July 2011. Retrieved 3 July 2012.
  15. ^ Thompson, A. J.; Heu, T; Shaghasi, T; Benyamino, R; Jones, A; Friis, E. P.; Wilson, K. S.; Davies, G. J. (2012). "Structure of the catalytic core module of the Chaetomium thermophilum family GH6 cellobiohydrolase Cel6A". Acta Crystallographica. D68 (8): 875–882. doi:10.1107/S0907444912016496.
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