BTF3

BTF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3
External IDsOMIM: 602542; MGI: 1202875; HomoloGene: 37453; GeneCards: BTF3; OMA:BTF3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207
NM_001037637
NM_001393652
NM_001393653

NM_001170540
NM_145455

RefSeq (protein)

NP_001032726
NP_001198

NP_001164011
NP_663430

Location (UCSC)Chr 5: 73.5 – 73.51 MbChr 13: 98.45 – 98.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.[5][6][7][8]

Function

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This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.[8]

Interactions

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BTF3 has been shown to interact with CSNK2B.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145741Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021660Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. Bibcode:1990Natur.344..556Z. doi:10.1038/344556a0. PMID 2320128. S2CID 4227320.
  6. ^ Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
  7. ^ Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
  8. ^ a b "Entrez Gene: BTF3 basic transcription factor 3".
  9. ^ Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.
[edit]
  • Human BTF3 genome location and BTF3 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor BTF3

Further reading

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