Butyrophilin, subfamily 2, member A2

BTN2A2
Identifiers
Aliases	BTN2A2, BT2.2, BTF2, BTN2.2, Butyrophilin, subfamily 2, member A2, butyrophilin subfamily 2 member A2
External IDs	OMIM: 613591; MGI: 3606486; HomoloGene: 56012; GeneCards: BTN2A2; OMA:BTN2A2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,394,874 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,673,027 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; lymph node; ; tonsil; ; granulocyte; ; appendix; ; monocyte; ; tendon of biceps brachii; ; spleen; ; pancreatic ductal cell; ; cerebellar cortex;
	Top expressed in
	embryo; ; embryo; ; secondary oocyte; ; morula; ; primary oocyte; ; epiblast; ; blastocyst; ; primary visual cortex; ; placenta; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; external side of plasma membrane; cell surface;
Biological process	negative regulation of activated T cell proliferation; negative regulation of cellular metabolic process; negative regulation of phosphatidylinositol 3-kinase signaling; positive regulation of regulatory T cell differentiation; regulation of immune response; T cell receptor signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of protein kinase B signaling; negative regulation of ERK1 and ERK2 cascade; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	10385
	238555
	ENSG00000124508
	ENSMUSG00000053216
	Q8WVV5
	A4QPC6
NM_001197237; NM_001197238; NM_001197239; NM_001197240; NM_006995;
	NM_181531
	NM_001289614; NM_001289615; NM_175938
NP_001184166; NP_001184167; NP_001184168; NP_001184169; NP_008926;
	NP_853509; NP_001184166.1; NP_008926.2
	NP_001276543; NP_001276544; NP_787952
	Wikidata
View/Edit Human	View/Edit Mouse

Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.^[5]^[6]^[7]

Function

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124508 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053216 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Henry J, Miller MM, Pontarotti P (June 1999). "Structure and evolution of the extended B7 family". Immunology Today. 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID 10354554.
^ Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (May 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Research. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
^ ^a ^b "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".

External links

BTN2A2 human gene location in the UCSC Genome Browser.
BTN2A2 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124508 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053216 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10354554-5] Henry J, Miller MM, Pontarotti P (June 1999). "Structure and evolution of the extended B7 family". Immunology Today. 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID 10354554.

[pmid9149941-6] Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (May 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Research. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.

[entrez-7] "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".

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Butyrophilin, subfamily 2, member A2

Function

References

Further reading

External links

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