ACTR1A

ACTR1A
Identifiers
Aliases	ACTR1A, ARP1, CTRN1, Arp1A, ARP1 actin-related protein 1 homolog A, centractin alpha, ARP1 actin related protein 1 homolog A, actin related protein 1A
External IDs	OMIM: 605143; MGI: 1858964; HomoloGene: 21173; GeneCards: ACTR1A; OMA:ACTR1A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,461,881 bp[1] End 102,502,712 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 46,365,250 bp[2] End 46,384,187 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence gastrocnemius muscle prefrontal cortex right frontal lobe stromal cell of endometrium muscle layer of sigmoid colon cingulate gyrus anterior cingulate cortex apex of heart C1 segment Top expressed in otic vesicle saccule spermatocyte otic placode spermatid facial motor nucleus lip ganglionic eminence external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding nucleotide binding protein binding cytoskeletal protein-membrane anchor activity Cellular component cytosol microtubule cytoskeleton microtubule associated complex cytoplasm myelin sheath centrosome microtubule organizing center cytoskeleton extracellular exosome dynactin complex manchette centriole COPI-coated vesicle cell cortex region cell cortex Biological process G2/M transition of mitotic cell cycle antigen processing and presentation of exogenous peptide antigen via MHC class II vesicle-mediated transport spermatogenesis ciliary basal body-plasma membrane docking endoplasmic reticulum to Golgi vesicle-mediated transport regulation of G2/M transition of mitotic cell cycle establishment of mitotic spindle orientation nuclear migration along microtubule Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10121 54130 Ensembl ENSG00000138107 ENSMUSG00000025228 UniProt P61163 P61164 RefSeq (mRNA) NM_005736 NM_016860 NM_001365070 RefSeq (protein) NP_005727 NP_058556 NP_001351999 Location (UCSC) Chr 10: 102.46 – 102.5 Mb Chr 19: 46.37 – 46.38 Mb PubMed search [3] [4]
Wikidata
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Alpha-centractin (yeast) or ARP1 is a protein that in humans is encoded by the ACTR1A gene.^[5][6]

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.^[6] ARP1 forms a 37 nm filament-like structure and is the core of the dynactin complex.^[7] It only exists in the dynactin complex in vivo. Highly purified, native Arp1 polymerize rapidly at extremely low concentrations into short filaments in vitro that were similar, but not identical, in length to those in dynactin. With time, these Arp1 filaments appeared to anneal to form longer assemblies but never attained the length of conventional actin filaments. As for conventional actin, Arp1 can bind and hydrolyze ATP, and Arp1 assembly is accompanied by nucleotide hydrolysis.^[8]

It has been reported that Arp1 interacts with other dynactin components including DCTN1/p150^Glued,^[9] DCTN4/p62^[10][11] and Actr10/Arp11.^[12] Arp1 has been shown as the domain for dynactin binding to membrane vesicles (such as Golgi or late endosome) through its association with β-spectrin.^{[13][14][15][16]}

ACTR1A has been shown to interact with SPTBN2.^[14][17]

• ACTR1A human gene location in the UCSC Genome Browser.
• ACTR1A human gene details in the UCSC Genome Browser.