Dimitri Kullmann

Dimitri Kullmann
FRS FMedSci MAE
Kullmann in 2018
Born
Dimitri Michael Kullmann

1958 (age 65–66)[4]
London, England[4]
EducationLycée Français Charles de Gaulle[4]
Alma materUniversity of Oxford
AwardsBaly Medal (2017)[1]
Scientific career
Fields
Institutions
ThesisCentral actions of muscle receptors (1984)
Doctoral advisorJulian Jack[3]
Websitewww.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann

Dimitri Michael Kullmann (born 1958)[4] is a British neurologist who is a professor of neurology at the UCL Institute of Neurology,[1] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust.[5] Kullmann is a member of the Queen Square Institute of Neurology Department of Clinical and Experimental Epilepsy[6] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery.[2][7]

Education

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Kullmann was educated at the Lycée Français Charles de Gaulle[4] and studied physiology at Balliol College, Oxford[4] where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree.[3] He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London.[1] His postgraduate research was supervised by Julian Jack.[3]

Research and career

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Kullmann's research[2][7] investigates how synapses function in health and disease.[8] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength.[8] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine.[8] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy.[8][2]

The Kullmann lab[2][7] has contributed to the discovery and elucidation of silent synapses,[9] glutamate spillover, tonic inhibition,[10] long-term potentiation in interneurons,[11] neurological channelopathies[12] and Synaptopathies, gene therapy for epilepsy,[13] and mechanisms of neural oscillations.[14] Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020[15] and is on the editorial board of the journal Neuron.[16] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco.[1]

Awards and honours

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Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986.[1] and the Baly Medal by the Royal College of Physicians in 2017.[1] He was elected a Guarantor of Brain in 2000,[17] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001,[18] a Corresponding Fellow of the American Neurological Association in 2013,[19] a member of the Academia Europaea (MAE) in 2017[20] and a Fellow of the Royal Society (FRS) in 2018.[8] He was awarded the 2023 Basic Science Research Award by the American Epilepsy Society.[21]

References

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  1. ^ a b c d e f g "Prof Dimitri Michael Kullmann: Iris View Profile". University College London. Retrieved 2 October 2016.
  2. ^ a b c d e f g h Dimitri Kullmann publications indexed by Google Scholar Edit this at Wikidata
  3. ^ a b c Kullman, Dimitri Michael (1984). Central actions of muscle receptors (DPhil thesis). University of Oxford. OCLC 59330270. EThOS uk.bl.ethos.353099. Archived from the original on 16 December 2019. Retrieved 6 June 2018.
  4. ^ a b c d e f Anon (2019). "Kullmann, Prof. Dimitri Michael". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  5. ^ "Synaptopathies". University College London. 17 July 2014. Retrieved 2 October 2016.
  6. ^ "DCEE". University College London. 29 May 2020. Retrieved 7 June 2021.
  7. ^ a b c Dimitri Kullmann publications from Europe PubMed Central
  8. ^ a b c d e Anon (2018). "Professor Dimitri Kullmann FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 May 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  9. ^ Kullmann, Dimitri M. (1994). "Amplitude fluctuations of". Neuron. 12 (5): 1111–1120. doi:10.1016/0896-6273(94)90318-2. PMID 7910467. S2CID 54357872.
  10. ^ Semyanov, Alexey; Walker, Matthew C.; Kullmann, Dimitri M.; Silver, R.Angus (2004). "Tonically active GABAA receptors: modulating gain and maintaining the tone". Trends in Neurosciences. 27 (5): 262–269. doi:10.1016/j.tins.2004.03.005. ISSN 0166-2236. PMID 15111008. S2CID 2660172.
  11. ^ Lamsa, Karri P.; Heeroma, Joost H.; Somogyi, Peter; Rusakov, Dmitri A.; Kullmann, Dimitri M. (2007). "Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit". Science. 315 (5816): 1262–1266. Bibcode:2007Sci...315.1262L. doi:10.1126/science.1137450. ISSN 1095-9203. PMC 3369266. PMID 17332410.
  12. ^ Kullmann, Dimitri M. (2010). "Neurological channelopathies". Annual Review of Neuroscience. 33: 151–172. doi:10.1146/annurev-neuro-060909-153122. ISSN 1545-4126. PMID 20331364.
  13. ^ Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie (2012). "Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. ISSN 1946-6242. PMC 3605784. PMID 23147003.
  14. ^ Akam, Thomas; Oren, Iris; Mantoan, Laura; Ferenczi, Emily; Kullmann, Dimitri M. (2012). "Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling". Nature Neuroscience. 15 (5): 763–768. doi:10.1038/nn.3081. ISSN 1546-1726. PMC 3378654. PMID 22466505.
  15. ^ "Editorial board | Brain". Brain.oxfordjournals.org. 26 September 2016. Archived from the original on 11 October 2014. Retrieved 2 October 2016.
  16. ^ "Editorial Board: Neuron". cell.com.
  17. ^ "Guarantors of Brain". Guarantors of Brain. Retrieved 11 August 2016.
  18. ^ "Professor Dimitri Kullmann FMedSci". acmedsci.ac.uk. Retrieved 2 October 2016.
  19. ^ "American Neurological Association (ANA)". Myana.org. Retrieved 1 November 2016.
  20. ^ Hoffmann, Ilire Hasani, Robert. "Academy of Europe: Kullmann Dimitri". ae-info.org.{{cite web}}: CS1 maint: multiple names: authors list (link)
  21. ^ "Dimitri M. Kullmann, D.Phil., FRS, FMedSci, MAE, Receives the 2023 Basic Science Research Award".

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