Euripedes Constantino Miguel

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Euripedes Constantino Miguel Filho (São Paulo, June 14, 1959) is an influential Brazilian psychiatrist, researcher, consultant, and professor. He graduated from the University of Sao Paulo Medical School (FMUSP). Currently, he is a full professor and head of the Department of Psychiatry at FMUSP and associate adjunct professor at the Yale University School of Medicine. Between 2009 and 2019, he was an associate professor in the Department of Psychiatry at Duke University (Durham, USA) and, from 2009 to 2014, a research consultant at Massachusetts General Hospital, Harvard Medical School.

As a researcher, he has published over 500 articles indexed in major international databases. These works have been cited more than 22,000 times, resulting in an h-index of 80 (Google Scholar) (MyResearcherID). In addition, he has edited 22 books.

He is currently a researcher at the Fundação de Amparo à Pesquisa do Estado de São Paulo - Fapesp (São Paulo Research Foundation) and a level 1A research productivity fellow at the Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (National Council for Scientific and Technological Development). He coordinates the Instituto Nacional de Ciência e Tecnologia de Psiquiatria do Desenvolvimento para Crianças e Adolescentes - INPD (National Institute of Developmental Psychiatry) and the Centro de Pesquisa e Inovação em Saúde Mental - CISM (National Center for Research and Innovation in Mental Health).

After completing his pre-university education at Colégio São Luís, Dr. Miguel entered the School of Medicine at the University of São Paulo, in 1977. He was involved in various academic activities during his studies. In 1979, he was president of the Associação Atlética Acadêmica Oswaldo Cruz and participated in activities organized by the Centro Acadêmico Oswaldo Cruz.

After completing his undergraduate degree, he entered the Medical Residency in General Psychiatry at the Psychiatry Institute of the Hospital das Clínicas, FMUSP. There, he was responsible for organizing general meetings as he completed a neurology internship and specialized in psychiatric consultation. At the end of his residency, he became a preceptor, leading activities involving undergraduate students and residents under the supervision of Professor Paulo Vaz de Arruda.

With his thesis concerning psychopathological changes in patients diagnosed with systemic lupus erythematosus, Dr. Miguel earned his doctorate under the supervision of Professor Valentim Gentil Filho.

Dr. Miguel completed a post-doctoral fellowship at Massachusetts General Hospital, Harvard Medical School, with Professor Michael Jenike as his principal supervisor.

In 1994, he was one of the founders of the Projeto de Transtornos do Espectro Obsessivo-Compulsivo - PROTOC (Obsessive-Compulsive Spectrum Disorders Program), a group he remains involved with to this day. With the members of this group, he coordinated three thematic projects funded by the São Paulo Research Foundation (Fapesp) and was the principal investigator of a project funded by the National Institutes of Health (NIH) focused on research into the neurobiological signature of OCD. Since 2023, he has been the principal investigator of a project at the National Institute of Mental Health (NIMH) focused on the genetic signature of OCD in a diverse sample of 5,000 patients in Latin America. Since 2004, he has coordinated the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders (C-TOC).

In 2003, he defended his habilitation thesis on Obsessive-Compulsive Spectrum Disorders.

Since 1992, Dr. Miguel has been researching various topics related to Obsessive-Compulsive Disorder (OCD), including comorbidities, enhancement of medications used in treatment, clinical characterization, biological markers, and neural circuit.

Recently, he has become responsible for the Child and Adolescent Psychiatry course in the Department of Psychiatry at the School of Medicine, USP, with the goal of advancing this field in the country. In this regard, his research aims to identify individuals at risk of developing mental health disorders and to investigate interventions to prevent these disorders, using the framework of developmental psychiatry.

Dr. Miguel coordinates the Instituto Nacional de Ciência e Tecnologia de Psiquiatria do Desenvolvimento para Crianças e Adolescentes - INCT/INPD (National Institute of Developmental Psychiatry). Established in 2008, the INPD was created with the goal of shifting the paradigm in psychiatric research from a focus on treating individuals who are already ill to a more proactive approach. The INPD’s innovative projects are aimed at developing methodologies to identify individuals at risk of developing mental health disorders, testing interventions to prevent them (focused on risk factors), and promoting mental health (focused on protective factors). The INPD was made possible through funding from major national funding agencies, CNPq and Fapesp.

Currently, Dr. Miguel coordinates the Centro de Pesquisa e Inovação em Saúde Mental - CISM (National Center for Research and Innovation in Mental Health), launched in 2023 to preserve and continue the legacy of INPD and with the purpose of advancing and disseminating knowledge about mental health. In addition to continuing research into genetic and environmental factors that precipitate mental disorders in children and adolescents, the research project implements new and more effective interventions in clinical practice through technology transfer to society. It also encourages social entrepreneurship by enabling the development of innovative digital mental health solutions.

Under Dr. Miguel's overall coordination, various projects are being developed at CISM to transform research findings into models that can be utilized by government agencies to directly impact or different segments of society.

Among these projects is the "Primeiros Laços" (First-ties) program, which promotes home visits by nurses to vulnerable pregnant adolescents and young women, aiming to foster child development and strengthen the emotional bonds between mother and baby from pregnancy through the child's second year. In 2018, the project won the Abril/DASA Social Medicine Award.

CISM also manages the "High Risk Cohort Project", a high-risk cohort study of mental health disorders, monitoring 2,500 children and adolescents in schools in São Paulo and Porto Alegre. This long-term study has created a database with hundreds of thousands of variables and will provide deeper and previously unreachable insights into the origins of mental health disorders.

In partnership with the Institute Ame Sua Mente, another ongoing project at CISM is "Saúde Mental nas Escolas" (Mental Health at School), which aims to provide mental health training for teachers through distance education strategies and improve well-being in the school environment.

In 2023, through CISM, the "Grand Open Innovation Challenge - GOIC" was launched, a talent program in science and innovation that encourages the proposal of technological solutions to address the major mental health needs of young people aged 14 to 24.

Among other projects, the research center is also developing digital solutions for broader mental health interventions, such as Conemo, a low-intensity digital psychotherapy app for common mental health disorders like depression, anxiety, and insomnia; Automated Reinforcement Management System – ARMS for alcohol use disorder; Exergame VR for adolescents with Attention Deficit/Hyperactivity Disorder (ADHD); and Motherly for maternal mental health.

With all these projects, CISM currently represents the largest mental health initiative in the country, involving resources amounting to 40 million reais from public (Fapesp) and private (Banco Industrial do Brasil - BIB) sources. It includes public universities (University of São Paulo - USP; Federal University of São Paulo - Unifesp; Federal University of Rio Grande do Sul - UFRGS; and State University of Campinas - Unicamp) and private institutions (UniMAX - Max Planck University Center and UniFAJ - Jaguariúna University Center), as well as the municipalities of Indaiatuba and Jaguariúna.

Dr. Miguel has an extensive history of collaboration with international researchers, including David Pauls, Michael Jenike, Scott Rauch, and Darin Dougherty from Harvard University (USA), and James Leckman from Yale University (USA).

In 2009, Miguel simultaneously took on the roles of Full Professor and Head of the Department of Psychiatry at the School of Medicine, University of São Paulo. In 2024, he was elected for the fifth time to hold this leadership position until 2026.

In 2012, Dr. Miguel received the 54th Jabuti Prize for the book “Clínica Psiquiátrica - A Visão do Departamento e do Instituto de Psiquiatria do HCFMUSP".

In 2018, the "Primeiros Laços" (First-ties) project, one of the early childhood intervention studies from INPD/CISM, won the Abril/DASA Social Medicine Award.

TORRES AR, SHAVITT RG, MIGUELEC. Medos, dúvidas e manias: orientações para pessoas com transtorno obsessivo-compulsivo e seus familiares. Porto Alegre : Artmed, 2013.^[1]

HOUNIE AG, MIGUEL EC. Tiques, cacoetes, Sindrome de Tourette. Um Manual para Pacientes, seus familiares, educadores e profissionais de saúde (2ª edição). ,Porto Alegre : Artmed, 2012.^[2]

MIGUEL EC, GENTIL FILHO V, GATTAZ W F. Clinica Psiquiátrica (2 volumes). Barueri, SP : Manole, 2011.

OLIVEIRA IR, ROSÁRIO MC, MIGUEL EC. Princípios e Prática em Transtorno Obsessivo- Compulsivo. Rio de Janeiro : Guanabara Koogan, 2007

LAFER B, ALMEIDA OP, FRÁGUAS JR, R,MIGUEL EC. Depressão no ciclo da vida. PortoAlegre: Artes Médicas Sul; 2000.

MIGUEL EC, RAUCH S, LECKMAN J.Neuropsychiatry of Basal Ganglia. Psychiatric Clinics of North America. Philadelphia: WB Saunders;20 (4); 1997.

Lopes AC, Greenberg BD, Canteras MM, Batistuzzo MC, Hoexter MQ, Gentil AF, Pereira CAB, Sampaio LANPC, Leite CC, Shavitt RG, Diniz JB, Busatto G, Norén G, Rasmussen SA, Miguel MC. Gamma ventral capsulotomy for obsessive-compulsive disorder: a double-blind, randomized controlled trial. JAMA Psychiatry in Press.

Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. J Neurosurg. 2014 Jul;121(1):123-30. doi: 10.3171/2014.2.JNS131423. Epub 2014 Apr 4.

de Mathis MA, Diniz JB, Hounie AG, Shavitt RG, Fossaluza V, Ferrão Y, Leckman JF, de Bragança Pereira C, do Rosario MC, Miguel EC. Trajectory in obsessive-compulsive disorder comorbidities. Eur Neuropsychopharmacol. 2013 Jul;23(7):594-601

Hoexter MQ, Dougherty DD, Shavitt RG, D'Alcante CC, Duran FL, Lopes AC, Diniz JB, Batistuzzo MC, Evans KC, Bressan RA, Busatto GF, Miguel EC. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive-compulsive disorder.Eur Neuropsychopharmacol. 2013 Jul;23(7):569-80

Torres AR, Ramos-Cerqueira AT, Ferrão YA, Fontenelle LF, do Rosário MC, Miguel EC. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. J Clin Psychiatry. 2011 Jan;72(1):17-26; quiz 119-20

Diniz JB, Shavitt RG, Fossaluza V, Koran L, Pereira CA, Miguel EC. A double-blind, randomized, controlled trial of fluoxetine plus quetiapine or clomipramine versus fluoxetine plus placebo for obsessive-compulsive disorder. J Clin Psychopharmacol. 2011 Dec;31(6):763-8

Miguel EC, Ferrão YA, Rosário MC, Mathis MA, Torres AR, Fontenelle LF, Hounie AG, Shavitt RG, Cordioli AV, Gonzalez CH, Petribú K, Diniz JB, Malavazzi DM, Torresan RC, Raffin AL, Meyer E, Braga DT, Borcato S, Valério C, Gropo LN, Prado Hda S, Perin EA, Santos SI, Copque H, Borges MC, Lopes AP, Silva ED; Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders. The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results. Rev Bras Psiquiatr. 2008 Sep;30(3):185-96.

Hounie AG, Pauls DL, do Rosario-Campos MC, Mercadante MT, Diniz JB, De Mathis MA, De Mathis ME, Chacon P, Shavitt RG, Curi M, Guilherme L, Miguel EC. Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. Biol Psychiatry. 2007 Feb 1;61(3):266-72.

Ferrão YA, Shavitt RG, Bedin NR, de Mathis ME, Carlos Lopes A, Fontenelle LF, Torres AR, Miguel EC. Clinical features associated to refractory obsessive-compulsive disorder. J Affect Disord. 2006 Aug;94(1-3):199-209

Rosario-Campos MC, Miguel EC, Quatrano S, et al. The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry. 2006 May;11(5):495-504

Miguel EC, Leckman JF, Rauch S, et al. Obsessive-compulsive disorder phenotypes: implications for genetic studies.Mol Psychiatry. 2005 Mar;10(3):258-75.

do Rosario-Campos MC, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early-onset obsessive-compulsive disorder.Am J Med Genet B Neuropsychiatr Genet. 2005

Maia AF, Pinto AS, Barbosa ER, Menezes PR, Miguel EC. Obsessive-compulsive symptoms, obsessive-compulsive disorder, and related disorders in Parkinson's disease.J Neuropsychiatry Clin Neurosci. 2003; 15(3):371-4.

Miguel EC, Shavitt RG, Ferrão YA, et al. How to treat OCD in patients with Tourette syndrome J Psychosom Res. 2003 Jul;55(1):49-57

Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry. 2001 Nov;158(11):1899-903

Miguel EC, do Rosário-Campos MC, Prado HS, et al. Sensory phenomena in obsessive-compulsive disorder and Tourette's disorder.J Clin Psychiatry. 2000 Feb;61(2):150-6; quiz 157.

Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The psychiatric symptoms of rheumatic fever. Am J Psychiatry. 2000 Dec;157(12):2036-8.

Miguel EC, Baer L, Coffey BJ, et al. Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome. Br J Psychiatry. 1997 Feb;170:140-5

Rauch SL, Savage CR, Alpert NM, Miguel EC, Baer L, Breiter HC, Fischman AJ, Manzo PA, Moretti C, Jenike MA. A positron emission tomographic study of simple phobic symptom provocation.Arch Gen Psychiatry. 1995 Jan;52(1):20-8

Miguel EC, Pereira RM, Pereira CA, Baer L, et al. Psychiatric manifestations of systemic lupus erythematosus: clinical features, symptoms, and signs of central nervous system activity in 43 patients. Medicine (Baltimore). 1994 Jul;73(4):224-32