HLA-A19
HLA-A19 (A19) is a human leukocyte antigen HLA-A serotype that may recognize the A29, A30, A31, A32, A33, and A74 serotypes.[1] While these haplotypes are found all over the globe, their combined frequencies are higher in Sub Saharan Africa; frequencies tend to decline away from Africa.
Clinical significance
[edit]HLA-A19 has been implicated in a number of diseases, including renal cell carcinoma, Kaposi's sarcoma, vitiligo, and others; antibodies to HLA-A19 were recorded in 86% of infertile men and 92% of infertile women.[1][2]
| Split antigen serotypes of A19 HLA-A |
| HLA-A29 |
| HLA-A30 |
| HLA-A31 |
| HLA-A32 |
| HLA-A33 |
| HLA-A74 |
References
[edit]- ^ a b Shankarkumar, Umapathy; Ghosh, Kanjaksha; Mohanty, Dipika (September 2002). "Defining the allelic variants of HLA A19 in the western Indian population". Human Immunology. 63 (9): 779–782. doi:10.1016/S0198-8859(02)00424-X.
- ^ Genco, Petrina V.; Mathur, Subbi; Oliver Williamson, H.; Rust, Philip F.; Glassman, Armand B.; Hugh Fudenberg, H. (1984-10-01). "Antibodies to A19 and Bw35 complexes of human leukocyte antigens are present in infertile subjects with sperm antibodies*†‡". Fertility and Sterility. 42 (4): 554–560. doi:10.1016/S0015-0282(16)48138-0. ISSN 0015-0282.