| Name | Latest stable release | Developer | License | Operating system or environment |
| Construct Animate (software) | 26 March 2024 | Scirra | Trialware | Web application |
| Blender | December 5, 2023 | Blender Foundation | GPL-2.0-or-later | Windows, OS X, Linux, FreeBSD |
| Adobe Character Animator | December 10, 2022 | Adobe Systems | Trialware | Windows, OS X |
| Motion | November 30, 2023 | Apple Inc. | Commercial proprietary software | OS X |
| TupiTube | August 15, 2020 | Maefloresta | GPL-2.0-or-later | Windows, OS X, Linux, other Unix-like |
| Synfig | May 19, 2024 | Robert Quattlebaum | GPL-2.0-or-later | Windows, OS X, Linux |
| Pencil2D | February 17, 2021 | Pencil2D Team | GPL-2.0-only | Windows, OS X, Linux, FreeBSD |
| Harmony | June 29, 2020 | Toon Boom Animation Inc. | Commercial Proprietary software Trialware | Windows, Mac OS X, Linux |
| CrazyTalk | January 22, 2016 | Reallusion, Inc | Trialware | Windows, OS X |
| Krita | 7 December 2023 | Krita Foundation, KDE | GPL-3.0-only | Windows, OS X, Linux, FreeBSD, Android |
| Adobe Animate | October 10, 2023 | Adobe Systems | Trialware | Windows, OS X |
| Live2D | September 4, 2019 | Live2D Ltd. | Trialware | Windows, OS X |
| Clip Studio Paint | March 14, 2024 | Celsys | Trialware | Windows, macOS, Android, iPadOS, iOS |
| Adobe After Effects | February 7, 2024 | Adobe Systems | Trialware | Windows, Mac OS X |
| OpenToonz | May 9, 2023 | Dwango | BSD-3-Clause | Windows, OS X, Linux |
| Wick Editor | December 5, 2016 | | GPL-3.0-or-later | Web application, Windows, Mac OS, Linux |
| Pivot Stickfigure Animator | July 26, 2021 | Peter Bone | Freeware | Windows |
| Moho (Anime Studio) | September 12, 2023 | Lost Marble LLC | Commercial Proprietary software Trialware | Windows, Mac OS X |
| DigiCel FlipBook | December 21, 2016 | DigiCel Inc. | Trialware | Windows, OS X |
| Apple iAd Producer | April 1, 2016 | Apple Inc. | Registerware | OS X |
| Toonz | April 12, 2021 | Digital Video S.p.a. | Commercial proprietary software | Windows, OS X, Mac OS |
| TVPaint Animation | December 22, 2022 | TVPaint Developpement | Commercial proprietary software | Windows, Mac OS X, Linux, Android |
| DrawPlus | March 23, 2015 | Serif | Commercial | Windows |
| SWFTools | April 8, 2012 | Matthias Kramm | GPL-2.0-or-later | Windows, OS X, Linux |
| Ajax Animator | December 31, 2011 | Antimatter15 | GPL-3.0-or-later | Web application |
| SWiSH Max | June 20, 2011 | SwishZone | Trialware | Windows |
| RETAS | | Celsys | Commercial proprietary software | Windows, OS X |
| ParticleIllusion | | | Trialware | Plug-in for Adobe After Effects |
| Flipnote Studio | December 24, 2008 | Nintendo | Freeware | Nintendo DS |
| Flipnote Studio 3D | July 24, 2013 | Nintendo | Freeware | Nintendo 3DS |
| Antics 2-D Animation | 1998 | Antics Workshop | Trialware | Windows |
| Autodesk Animator Pro | 1995 | Jim Kent | Freeware/Open source | MS-DOS, Windows |
| Autodesk Animator Studio | 1995 | Autodesk | Commercial proprietary software | MS-DOS, Windows |
| Fantavision | 1988 | Broderbund | Discontinued commercial proprietary software | Apple II, Amiga, Apple IIGS, MS-DOS |
| Glaxnimate | September 11, 2022 | Mattia Basaglia | GPL-3.0-or-later | Linux, macOS, Windows, FreeBSD |
| FlipaClip | | Visual Blasters | Freeware | Windows, macOS, Android, iOS |
| Enve | September 25, 2022[1] | Maurycy Liebner | GPL-3.0-only | Windows, Linux |
