List of estrogens

Estradiol, the prototypical estrogen.
Steroid ring system.

This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead.

Estradiol derivatives

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Compound Chemical name Structure Marketed
Estradiol (E2) Estra-1,3,5(10)-triene-3,17β-diol ✓
2-Hydroxyestradiol 2-Hydroxyestradiol –
4-Hydroxyestradiol 4-Hydroxyestradiol –
4-Methoxyestradiol 4-Methoxyestradiol –
8β-VE2 8β-Vinylestradiol –
16α-IE2 16α-Iodoestradiol –
16α-LE2 Estradiol 21,16α-lactone? –
Cloxestradiol Estradiol 17β-chloral hemiacetal ether –
Cloxestradiol acetate Estradiol 17β-chloral hemiacetal ether O,O-diacetate ✓
Estradiol sulfate Estradiol 3-sulfate –
Estrapronicate Estradiol 3-propionate 17β-nicotinate ✓
Orestrate Estradiol 3-propionate 17β-(1-cyclohexenyl) ether –
Polyestradiol phosphate Estradiol 17β-phosphate polymer ✓
Promestriene Estradiol 3-propyl 17β-methyl diether ✓

17α-Substituted estradiol derivatives

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Compound Chemical name Structure Marketed
Cyclodiol 14α,17α-Ethanoestradiol –
Estrazinol 8-Aza-17α-ethynylestradiol 3-methyl ether –
Estrofurate 17α-(3-Furyl)-δ7-estradiol 3-acetate –
Etamestrol (eptamestrol) 1-Hydroxy-7α-methyl-17α-ethynylestradiol 1,3-dibenzoate –
Ethinylestradiol (EE) 17α-Ethynylestradiol ✓
Ethinylestradiol sulfonate (EES) 17α-Ethynylestradiol 3-isopropylsulfonate ✓
Ethylestradiol 17α-Ethylestradiol –
Mestranol (EE3ME) 17α-Ethynylestradiol 3-methyl ether ✓
Methylestradiol 17α-Methylestradiol ✓
Moxestrol 11β-Methoxy-17α-ethynylestradiol ✓
Quinestrol 17α-Ethynylestradiol 3-cyclopentyl ether ✓
RU-16117 11α-Methoxy-17α-ethynylestradiol –

Nitrogen mustard-coupled alkylating antineoplastic estradiol derivatives

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Compound Chemical name Structure Marketed
Alestramustine Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(2β-aminopropanoate) –
Atrimustine Estradiol 3-benzoate 17β-(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate –
Estramustine Estradiol 3-(bis(2-chloroethyl)carbamate) –
Estramustine phosphate Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-phosphate ✓

17β-Aminoestrogens

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See also: 17β-Aminoestrogen
Compound Chemical name Structure Marketed
Aminoestradiol 17β-Aminoestradiol –
Butolame 17β-((4-Hydroxybutyl)amino)estradiol –
Hexolame 17β-((6-Hydroxyhexyl)amino)estradiol –
Pentolame 17β-((5-Hydroxypentyl)amino)estradiol –
Prodiame 17β-((3-Aminopropyl)amino)estradiol –
Prolame 17β-((3-Hydroxypropyl)amino)estradiol –

Estrone derivatives

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Compound Chemical name Structure Marketed
Estrone (E1) Estra-1,3,5(10)-triene-3-ol-17-one ✓
2-Hydroxyestrone 2-Hydroxyestrone –
4-Hydroxyestrone 4-Hydroxyestrone –
4-Methoxyestrone 4-Methoxyestrone –
16α-Hydroxyestrone 16α-Hydroxyestrone –
Almestrone 7α-Methylestrone ✓
Clomestrone 16α-Chloroestrone 3-methyl ether ✓
Estrone sulfate Estrone 3-sulfate ✓
Estropipate Estrone 3-sulfate piperazine salt ✓
Hydroxyestrone diacetate 16α-Hydroxyestrone 3,16α-diacetate ✓

Nitrogen mustard-coupled alkylating antineoplastic estrone derivatives

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Compound Chemical name Structure Marketed
Estromustine Estrone 3-(bis(2-chloroethyl)carbamate) –

Estriol derivatives

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Compound Chemical name Structure Marketed
Estriol (E3) 16α-Hydroxyestradiol ✓
Estetrol (E4) 15α-Hydroxyestriol –
Quinestradol Estriol 3-cyclopentyl ether ✓

17α-Substituted estriol derivatives

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Compound Chemical name Structure Marketed
Cyclotriol 14α,17α-Ethanoestriol –
Ethinylestriol 17α-Ethynylestriol –
Nilestriol 17α-Ethynylestriol 3-cyclopentyl ether ✓

Other estrogen derivatives

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Epimers

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Compound Chemical name Structure Marketed
17α-Estradiol (alfatradiol) 17α-Estradiol ✓
16β-Epiestriol (epiestriol) 16β-Hydroxy-17β-estradiol ✓
17α-Epiestriol 16α-Hydroxy-17α-estradiol –
16β,17α-Epiestriol 16β-Hydroxy-17α-estradiol –
Epimestrol 17α-Epiestriol 3-methyl ether ✓
Mytatrienediol 16α-Methyl-16β-epiestriol 3-methyl ether –

Equine estrogens

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See also: Conjugated estrogens and Esterified estrogens
Compound Chemical name Structure Marketed
Equilin Δ7-Estrone ✓
Equilenin Δ6,8-Estrone ✓
17α-Dihydroequilin Δ7-17α-Estradiol ✓
17β-Dihydroequilin Δ7-17β-Estradiol ✓
17α-Dihydroequilenin Δ6,8-17α-Estradiol ✓
17β-Dihydroequilenin Δ6,8-17β-Estradiol ✓
8,9-Dehydroestrone Δ8-Estrone ✓
8,9-Dehydroestradiol Δ8-17β-Estradiol ✓
Hippulin Δ8-14-Isoestrone ✓

See also

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Notes

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? = Chemical names that are unverified.

References

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