Octadecanoid pathway

The octadecanoid pathway is a biosynthetic pathway for the production of the phytohormone jasmonic acid (JA), an important hormone for induction of defense genes. JA is synthesized from alpha-linolenic acid, which can be released from the plasma membrane by certain lipase enzymes. For example, in the wound defense response, phospholipase C will cause the release of alpha-linolenic acid for JA synthesis.

In the first step, alpha-linolenic acid is oxidized by the enzyme lipoxygenase. This forms 13-hydroperoxylinolenic acid, which is then modified by a dehydrase and undergoes cyclization by allene oxide cyclase to form 12-oxo-phytodienoic acid. This undergoes reduction and three rounds of beta oxidation to form jasmonic acid.^[1]

• Peter J Davies (30 April 1995). Plant Hormones: Physiology, Biochemistry and Molecular Biology. Kluwer Academic Press. p. 836. ISBN 978-0-7923-2985-5.
• Hans Weber (2002). "Fatty acid-derived signals in plants". Trends in Plant Science. 7 (5): 217–224. doi:10.1016/S1360-1385(02)02250-1. PMID 11992827.

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