PRIMA1
| PRIMA1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PRIMA1, PRIMA, proline rich membrane anchor 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613851; MGI: 1926097; HomoloGene: 15783; GeneCards: PRIMA1; OMA:PRIMA1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[4][5]
Function
[edit]PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[4] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[6] The PRAD interacts with the C-terminal T-peptide of AChE.[7]
PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[5] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.
Clinical significance
[edit]The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[8]
References
[edit]- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041669 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: proline rich membrane anchor 1".
- ^ a b Perrier AL, Massoulié J, Krejci E (Jan 2002). "PRiMA: the membrane anchor of acetylcholinesterase in the brain". Neuron. 33 (2): 275–85. doi:10.1016/S0896-6273(01)00584-0. PMID 11804574.
- ^ Xie HQ, Siow NL, Peng HB, Massoulié J, Tsim KW (Dec 2005). "Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle". Chemico-Biological Interactions. 157–158: 432. Bibcode:2005CBI...157..432X. doi:10.1016/j.cbi.2005.10.093. PMID 16429581.
- ^ Perrier NA, Khérif S, Perrier AL, Dumas S, Mallet J, Massoulié J (Oct 2003). "Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase". The European Journal of Neuroscience. 18 (7): 1837–47. doi:10.1046/j.1460-9568.2003.02914.x. PMID 14622217. S2CID 21808922.
- ^ Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (Sep 1983). "Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form". Neuroscience Letters. 40 (2): 199–204. doi:10.1016/0304-3940(83)90302-6. PMID 6633975. S2CID 45149066.
Further reading
[edit]- Vanaja DK, Ballman KV, Morlan BW, Cheville JC, Neumann RM, Lieber MM, Tindall DJ, Young CY (Feb 2006). "PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer". Clinical Cancer Research. 12 (4): 1128–36. doi:10.1158/1078-0432.CCR-05-2072. PMID 16489065.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Xie HQ, Choi RC, Leung KW, Chen VP, Chu GK, Tsim KW (Apr 2009). "Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation". Brain Research. 1265: 13–23. doi:10.1016/j.brainres.2009.01.065. PMID 19368807. S2CID 26943639.
- Xie HQ, Liang D, Leung KW, Chen VP, Zhu KY, Chan WK, Choi RC, Massoulié J, Tsim KW (Apr 2010). "Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons". The Journal of Biological Chemistry. 285 (15): 11537–46. doi:10.1074/jbc.M109.038711. PMC 2857032. PMID 20147288.
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