RASA3

RASA3
Identifiers
AliasesRASA3, GAP1IP4BP, GAPIII, RAS p21 protein activator 3
External IDsOMIM: 605182; MGI: 1197013; HomoloGene: 7217; GeneCards: RASA3; OMA:RASA3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007368
NM_001320821
NM_001320822

NM_009025

RefSeq (protein)

NP_001307750
NP_001307751
NP_031394

NP_033051

Location (UCSC)Chr 13: 113.98 – 114.13 MbChr 8: 13.62 – 13.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.[5][6][7]

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.[7]

Interactions

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RASA3 has been shown to interact with HCK.[8]

References

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  1. ^ a b c ENSG00000185989 GRCh38: Ensembl release 89: ENSG00000280477, ENSG00000185989Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031453Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF (Sep 1995). "Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family". Nature. 376 (6540): 527–30. Bibcode:1995Natur.376..527C. doi:10.1038/376527a0. PMID 7637787. S2CID 4283160.
  6. ^ Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ (Feb 1998). "Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting". Curr Biol. 7 (12): 1007–10. doi:10.1016/S0960-9822(06)00423-4. PMID 9382842.
  7. ^ a b "Entrez Gene: RASA3 RAS p21 protein activator 3".
  8. ^ Briggs SD, Bryant S S, Jove R, Sanderson S D, Smithgall T E (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. 270 (24). UNITED STATES: 14718–24. doi:10.1074/jbc.270.24.14718. ISSN 0021-9258. PMID 7782336.

Further reading

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