Protein-coding gene in the species Homo sapiens
SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85 [ 5] , in rodents - Ruk [ 6] ) is an adaptor protein that in humans is encoded by the SH3KBP1 gene .[ 7] [ 8]
CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][ 9]
SH3KBP1 has been shown to interact with B-cell linker ,[ 10] Grb2 ,[ 11] [ 12] SH3GLB2 ,[ 13] [ 14] SH3GL3 ,[ 13] SH3GL2 ,[ 14] BCAR1 ,[ 10] Epidermal growth factor receptor ,[ 14] [ 15] CBLB ,[ 15] Cbl gene ,[ 10] [ 12] [ 13] [ 14] [ 15] SOS1 ,[ 10] CRK [ 10] PAK2 .[ 16]
^ a b c GRCh38: Ensembl release 89: ENSG00000147010 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040990 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Database GH. "SH3KBP1 Gene - GeneCards | SH3K1 Protein | SH3K1 Antibody" . www.genecards.org . Retrieved 2017-12-28 . ^ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein" . The EMBO Journal . 19 (15): 4015–25. doi :10.1093/emboj/19.15.4015 . PMC 306608 PMID 10921882 . ^ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags" . Genome Research . 6 (9): 807–28. doi :10.1101/gr.6.9.807 PMID 8889549 . ^ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 . ^ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1" .^ a b c d e Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes" . Biochemical and Biophysical Research Communications . 278 (1): 167–74. doi :10.1006/bbrc.2000.3760 . PMID 11071869 . ^ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein" . The EMBO Journal . 19 (15): 4015–25. doi :10.1093/emboj/19.15.4015 . PMC 306608 PMID 10921882 . ^ a b Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling . 12 (11–12): 769–79. doi :10.1016/S0898-6568(00)00129-7 . PMID 11152963 . ^ a b c Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. Bibcode :2002Natur.416..187P . doi :10.1038/416187a . PMID 11894096 . S2CID 4389099 . ^ a b c d Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . 416 (6877): 183–7. Bibcode :2002Natur.416..183S . doi :10.1038/416183a . PMID 11894095 . S2CID 635702 . ^ a b c Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases" . The Journal of Biological Chemistry . 277 (42): 39666–72. doi :10.1074/jbc.M205535200 PMID 12177062 . ^ Kurakin AV, Wu S, Bredesen DE (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening" . The Journal of Biological Chemistry . 278 (36): 34102–9. doi :10.1074/jbc.M305264200 PMID 12829691 . Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D (March 1998). "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN" . The Journal of Biological Chemistry . 273 (12): 6989–97. doi :10.1074/jbc.273.12.6989 PMID 9507006 . Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion" . The EMBO Journal . 17 (24): 7320–36. doi :10.1093/emboj/17.24.7320 . PMC 1171078 PMID 9857189 . Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S (February 2000). "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl" . Biochemical and Biophysical Research Communications . 268 (2): 321–8. doi :10.1006/bbrc.2000.2147 . PMID 10679202 . Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O (June 2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes" . The Journal of Biological Chemistry . 275 (25): 19275–81. doi :10.1074/jbc.M908994199 PMID 10858458 . Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein" . The EMBO Journal . 19 (15): 4015–25. doi :10.1093/emboj/19.15.4015 . PMC 306608 PMID 10921882 . Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes" . Biochemical and Biophysical Research Communications . 278 (1): 167–74. doi :10.1006/bbrc.2000.3760 . PMID 11071869 . Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling . 12 (11–12): 769–79. doi :10.1016/S0898-6568(00)00129-7 . PMID 11152963 . Narita T, Amano F, Yoshizaki K, Nishimoto N, Nishimura T, Tajima T, Namiki H, Taniyama T (2001). "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization". Cytogenetics and Cell Genetics . 93 (1–2): 133–4. doi :10.1159/000056966 . PMID 11474197 . S2CID 30342776 . Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . 416 (6877): 183–7. Bibcode :2002Natur.416..183S . doi :10.1038/416183a . PMID 11894095 . S2CID 635702 . Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. Bibcode :2002Natur.416..187P . doi :10.1038/416187a . PMID 11894096 . S2CID 4389099 . Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (August 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1" . The Journal of Biological Chemistry . 277 (31): 28238–46. doi :10.1074/jbc.M202783200 PMID 12029088 . Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I (July 2002). "Ruk is ubiquitinated but not degraded by the proteasome" . European Journal of Biochemistry . 269 (14): 3402–8. doi :10.1046/j.1432-1033.2002.03031.x PMID 12135478 . Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases" . The Journal of Biological Chemistry . 277 (42): 39666–72. doi :10.1074/jbc.M205535200 PMID 12177062 . Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (September 2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors" . Proceedings of the National Academy of Sciences of the United States of America . 99 (19): 12191–6. Bibcode :2002PNAS...9912191H . doi :10.1073/pnas.192462299 PMC 129420 PMID 12218189 . Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N (July 2002). "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues". Gene . 295 (1): 13–17. doi :10.1016/S0378-1119(02)00821-1 . PMID 12242006 . Tibaldi EV, Reinherz EL (March 2003). "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities" . International Immunology . 15 (3): 313–29. doi :10.1093/intimm/dxg032 PMID 12618476 . Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH (June 2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85" . The Journal of Biological Chemistry . 278 (25): 22396–403. doi :10.1074/jbc.M302540200 PMID 12690097 .
PDB gallery
1wi7 : Solution structure of the SH3 domain of SH3-domain kinase binding protein 1
2bz8 : N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE
2da9 : Solution structure of the third SH3 domain of SH3-domain kinase binding protein 1 (Regulator of ubiquitous kinase, Ruk)
