Sarcophagine
 | |
| Names | |
|---|---|
| Preferred IUPAC name 3,6,10,13,16,19-Hexazabicyclo[6.6.6]icosane | |
| Other names Sar chelate | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
PubChem CID | |
CompTox Dashboard (EPA) | |
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| Properties | |
| C14H32N6 | |
| Molar mass | 284.452 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Sarcophagine (Sar) is a bicyclic cage-like metal chelator molecule[1] derived from cyclam. Chemical formula of sarcophagine is 3,6,10,13,16,19-hexaazabicyclo(6,6,6)icosane[2] and additional functional groups are often linked to this structure, such as in DiAmSar (1,8-diamino-Sar). This and many related hexadentate clathrochelates are prepared by template reactions.[3]
Chemical structure of DiAmSar
Sarcophagine derivatives are used, for example, as ligands in radiopharmaceuticals that require incorporating a radioactive metal cation into an organic and/or biological structure, such as an antibody.[4]
References
[edit]- ^ Liu, Shuanglong; Li, Dan; Huang, Chiun-Wei; Yap, Li-Peng; Park, Ryan; Shan, Hong; Li, Zibo; Conti, Peter S. (2012). "The Efficient Synthesis and Biological Evaluation of Novel Bi-Functionalized Sarcophagine for 64Cu Radiopharmaceuticals". Theranostics. 2 (6): 589–596. doi:10.7150/thno.4295. PMC 3381345. PMID 22737194. Retrieved 2017-10-06.
- ^ Pubchem. "Diamsar chelate". pubchem.ncbi.nlm.nih.gov. Retrieved 2017-10-06.
- ^ Gahan, L. R.; Harrowfield, J. M. (2015). "Sepulchrate: Four decades on". Polyhedron. 94: 1–51. doi:10.1016/j.poly.2015.03.036.
- ^ Liu, Shuanglong; Li, Zibo; Conti, Peter S. (2014-04-03). "Development of Multi-Functional Chelators Based on Sarcophagine Cages". Molecules. 19 (4): 4246–4255. doi:10.3390/molecules19044246. PMC 6270798. PMID 24705567.