t(11:14)

Overview of some chromosomal translocations involved in different cancers, as well as implicated in some other conditions, e.g. schizophrenia,[1] with chromosomes arranged in standard karyogram order. t(11;14) is seen in center. Abbreviations:
ALL – Acute lymphoblastic leukemia
AML – Acute myeloid leukemia
CML – Chronic myelogenous leukemia
DFSP – Dermatofibrosarcoma protuberans

t(11;14) is a chromosomal translocation which essentially always involves the immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14, as well as cyclin D1 which is located in the q13 of chromosome 11 .[2] Specifically, the translocation is at t(11;14)(q13;q32).[3][4]

The translocation is mainly found in mantle cell lymphoma, but also in B-cell prolymphocytic leukemia, in plasma cell leukemia, in splenic lymphoma with villous lymphocytes, in chronic lymphocytic leukemia, and in multiple myeloma. All these diseases involve B-lineage lymphocytes.[2]

Prognosis

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In multiple myeloma, t(11;14) is a neutral prognostic factor in general, but it may confer a worse prognosis for overall survival in African American people with multiple myeloma.[5]

References

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  1. ^ Semple CA, Devon RS, Le Hellard S, Porteous DJ (April 2001). "Identification of genes from a schizophrenia-linked translocation breakpoint region". Genomics. 73 (1): 123–6. doi:10.1006/geno.2001.6516. PMID 11352574.
  2. ^ a b Jean-Loup Huret (1998-05-01). "t(11;14)(q13;q32) IGH/CCND1". Atlas Genet Cytogenet Oncol Haematol.
  3. ^ Li JY, Gaillard F, Moreau A, et al. (May 1999). "Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization". Am. J. Pathol. 154 (5): 1449–52. doi:10.1016/S0002-9440(10)65399-0. PMC 1866594. PMID 10329598.
  4. ^ Barouk-Simonet E, Andrieux J, Copin MC, et al. (2002). "TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma". Ann. Genet. 45 (3): 165–8. doi:10.1016/S0003-3995(02)01122-X. PMID 12381451.
  5. ^ Gasparetto C, Jagannath S, Rifkin RM, Durie BGM, Narang M, Terebelo HR; et al. (2022). "Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry". Clin Lymphoma Myeloma Leuk. 22 (3): 149–157. doi:10.1016/j.clml.2021.08.007. PMID 34588149.{{cite journal}}: CS1 maint: multiple names: authors list (link)


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