Protein-coding gene in the species Homo sapiens
Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene .[ 5] [ 6]
This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[ 6]
TRERF1 has been shown to interact with Steroidogenic factor 1 ,[ 7] EP300 [ 5] CREB-binding protein .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000124496 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064043 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression" . The Journal of Biological Chemistry . 276 (36): 33881–92. doi :10.1074/jbc.M100113200 PMID 11349124 . ^ a b "Entrez Gene: TRERF1 transcriptional regulating factor 1" .^ Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells" . The Journal of Biological Chemistry . 277 (42): 39144–55. doi :10.1074/jbc.M205786200 PMID 12101186 . Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells" . The Journal of Biological Chemistry . 277 (42): 39144–55. doi :10.1074/jbc.M205786200 PMID 12101186 . Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, et al. (November 2002). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression". Endocrine Research . 28 (4): 559–74. doi :10.1081/ERC-120016841 . PMID 12530663 . S2CID 22485023 . Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW (April 2004). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells" . Journal of Molecular Endocrinology . 32 (2): 557–69. doi :10.1677/jme.0.0320557 PMID 15072559 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, et al. (June 2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1" . Molecular and Cellular Biology . 25 (11): 4335–48. doi :10.1128/MCB.25.11.4335-4348.2005 . PMC 1140623 PMID 15899840 . Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, et al. (October 2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone" . Molecular and Cellular Biology . 26 (20): 7632–44. doi :10.1128/MCB.00326-06 . PMC 1636875 PMID 17015480 .
