UGT1A7 (gene)
UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.[5]
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008].[5]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000244122 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090175 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: UDP glucuronosyltransferase 1 family, polypeptide A7". Retrieved 2012-01-27.
Further reading
[edit]- Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annual Review of Pharmacology and Toxicology. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
- Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE (October 2000). "Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene". Pharmacogenetics. 10 (7): 629–44. doi:10.1097/00008571-200010000-00006. PMID 11037804.
- Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC (June 2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
- King CD, Rios GR, Green MD, Tephly TR (September 2000). "UDP-glucuronosyltransferases". Current Drug Metabolism. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080.
- Zheng Z, Park JY, Guillemette C, Schantz SP, Lazarus P (September 2001). "Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk". Journal of the National Cancer Institute. 93 (18): 1411–8. doi:10.1093/jnci/93.18.1411. PMID 11562393.
- Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, Strassburg CP (November 2001). "Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene". Gastroenterology. 121 (5): 1136–44. doi:10.1053/gast.2001.28655. PMID 11677206.
- Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP (June 2002). "Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer". Gut. 50 (6): 851–6. doi:10.1136/gut.50.6.851. PMC 1773251. PMID 12010889.
- Vogel A, Ockenga J, Ehmer U, Barut A, Kramer FJ, Tukey RH, Manns MP, Strassburg CP (July 2002). "Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer". Zeitschrift für Gastroenterologie. 40 (7): 497–502. doi:10.1055/s-2002-32805. PMID 12122597. S2CID 32252828.
- Köhle C, Möhrle B, Münzel PA, Schwab M, Wernet D, Badary OA, Bock KW (May 2003). "Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians". Biochemical Pharmacology. 65 (9): 1521–7. doi:10.1016/S0006-2952(03)00074-1. PMID 12732365.
- Ockenga J, Vogel A, Teich N, Keim V, Manns MP, Strassburg CP (June 2003). "UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer". Gastroenterology. 124 (7): 1802–8. doi:10.1016/s0016-5085(03)00294-4. PMID 12806614.
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