U of SA
U of SA, U. of SA, U of S.A., or U. of S.A. may refer to:
- University of South Africa, in South Africa
- University of Texas at San Antonio, in Texas
- University of San Antonio, in Texas
- University of St Andrews, in the United Kingdom
- University of Saint Anthony, in the Philippines
- Union of South Africa, the official name of South Africa from 1910 to 1961