ZEB2-AS1

ZEB2-AS1
Identifiers
Aliases	ZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT, ZEB2 antisense RNA 1
External IDs	GeneCards: ZEB2-AS1; OMA:ZEB2-AS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	144,521,477 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; corpus callosum; ; bone marrow cells; ; Achilles tendon; ; testicle; ; C1 segment; ; epithelium of colon; ; sural nerve; ; substantia nigra;
	n/a
	More reference expression data
	n/a
Orthologs
	100303491
	n/a
	ENSG00000238057
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene.^[3]^[4] It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000238057 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K (October 2003). "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics. 82 (4): 460–469. doi:10.1016/S0888-7543(03)00169-1. PMID 13679026.
^ ^a ^b Beltran M, Puig I, Peña C, et al. (March 2008). "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev. 22 (6): 756–769. doi:10.1101/gad.455708. PMC 2275429. PMID 18347095.