EXTL2

EXTL2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1OMX, 1OMZ, 1ON6, 1ON8

Identifikatori
AliasiEXTL2
Vanjski ID-jeviOMIM: 602411 MGI: 1889574 HomoloGene: 1102 GeneCards: EXTL2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za EXTL2
Genomska lokacija za EXTL2
Bend1p21.2Početak100,872,372 bp[1]
Kraj100,895,179 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za EXTL2
Genomska lokacija za EXTL2
Bend3|3 G1Početak115,801,111 bp[2]
Kraj115,822,666 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
vezivanje iona metala
glycosyltransferase activity
glycosaminoglycan binding
manganese ion binding
alpha-1,4-N-acetylgalactosaminyltransferase activity
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
Ćelijska komponenta integral component of membrane
extracellular region
Endoplazmatski retikulum
membrana
endoplasmic reticulum membrane
Biološki proces heparan sulfate proteoglycan biosynthetic process
N-acetylglucosamine metabolic process
UDP-N-acetylgalactosamine metabolic process
IRE1-mediated unfolded protein response
GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001033025
NM_001261440
NM_001261441
NM_001261442
NM_001439

NM_001163514
NM_001163515
NM_021388

RefSeq (bjelančevina)

NP_001028197
NP_001248369
NP_001248370
NP_001248371
NP_001430

NP_001156986
NP_001156987
NP_067363

Lokacija (UCSC)Chr 1: 100.87 – 100.9 MbChr 3: 115.8 – 115.82 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Egzostozinoliki protein 2 jest protein koji je kod ljudi kodiran genom EXTL2 sa hromosoma 1.[5][6][7]

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 330 aminokiselina, a molekulska težina 37.466 Da.[8]

1020304050
MRCCHICKLPGRVMGIRVLRLSLVVILVLLLVAGALTALLPSVKEDKMLM
LRREIKSQGKSTMDSFTLIMQTYNRTDLLLKLLNHYQAVPNLHKVIVVWN
NIGEKAPDELWNSLGPHPIPVIFKQQTANRMRNRLQVFPELETNAVLMVD
DDTLISTPDLVFAFSVWQQFPDQIVGFVPRKHVSTSSGIYSYGSFEMQAP
GSGNGDQYSMVLIGASFFNSKYLELFQRQPAAVHALIDDTQNCDDIAMNF
IIAKHIGKTSGIFVKPVNMDNLEKETNSGYSGMWHRAEHALQRSYCINKL
VNIYDSMPLRYSNIMISQFGFPYANYKRKI

Funkcija

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EXTL2 glikoziltransferaza potrebna je za biosintezu heparan-sulfata i odgovorna je za naizmjenično dodavanje beta-1-4-vezane glukuronske kiseline (GlcA) i alfa-1-4-vezanih N-acetilglukozamin (GlcNAc) jedinica u nastajajuće heparan-sulfatne lance. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162694 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027963 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
  6. ^ Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.
  7. ^ "Entrez Gene: EXTL2 exostoses (multiple)-like 2".
  8. ^ "UniProt, Q9UBQ6" (jezik: engleski). Pristupljeno 25. 11. 2021.

Dopunska literatura

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Vanjski linkovi

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2