GON4L
GON-4-liki protein jest protein koji je kod ljudi kodiran genom GON4L sa hromosoma 1.[5][6] To je jedarni protein koji sadrži dva serinskog fosfozita i poprečnu vezu lizin–glutamin [7] i smatra se da je transkripcijski faktor.[8]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 2.241 aminokiselina, a molekulska težina 248.620 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLPCKKRRTT | VTESLQHKGN | QEENNVDLES | AVKPESDQVK | DLSSVSLSWD | ||||
| PSHGRVAGFE | VQSLQDAGNQ | LGMEDTSLSS | GMLTQNTNVP | ILEGVDVAIS | ||||
| QGITLPSLES | FHPLNIHIGK | GKLHATGSKR | GKKMTLRPGP | VTQEDRCDHL | ||||
| TLKEPFSGEP | SEEVKEEGGK | PQMNSEGEIP | SLPSGSQSAK | PVSQPRKSTQ | ||||
| PDVCASPQEK | PLRTLFHQPE | EEIEDGGLFI | PMEEQDNEES | EKRRKKKKGT | ||||
| KRKRDGRGQE | GTLAYDLKLD | DMLDRTLEDG | AKQHNLTAVN | VRNILHEVIT | ||||
| NEHVVAMMKA | AISETEDMPM | FEPKMTRSKL | KEVVEKGVVI | PTWNISPIKK | ||||
| ANEIKPPQFV | DIHLEEDDSS | DEEYQPDDEE | EDETAEESLL | ESDVESTASS | ||||
| PRGAKKSRLR | QSSEMTETDE | ESGILSEAEK | VTTPAIRHIS | AEVVPMGPPP | ||||
| PPKPKQTRDS | TFMEKLHAVD | EELASSPVCM | DSFQPMDDSL | IAFRTRSKMP | ||||
| LKDVPLGQLE | AELQAPDITP | DMYDPNTADD | EDWKMWLGGL | MNDDVGNEDE | ||||
| ADDDDDPEYN | FLEDLDEPDT | EDFRTDRAVR | ITKKEVNELM | EELFETFQDE | ||||
| MGFSNMEDDG | PEEEECVAEP | RPNFNTPQAL | RFEEPLANLL | NEQHRTVKEL | ||||
| FEQLKMKKSS | AKQLQEVEKV | KPQSEKVHQT | LILDPAQRKR | LQQQMQQHVQ | ||||
| LLTQIHLLAT | CNPNLNPEAT | TTRIFLKELG | TFAQSSIALH | HQYNPKFQTL | ||||
| FQPCNLMGAM | QLIEDFSTHV | SIDCSPHKTV | KKTANEFPCL | PKQVAWILAT | ||||
| SKVFMYPELL | PVCSLKAKNP | QDKIVFTKAE | DNLLALGLKH | FEGTEFPNPL | ||||
| ISKYLLTCKT | AHQLTVRIKN | LNMNRAPDNI | IKFYKKTKQL | PVLGKCCEEI | ||||
| QPHQWKPPIE | REEHRLPFWL | KASLPSIQEE | LRHMADGARE | VGNMTGTTEI | ||||
| NSDRSLEKDN | LELGSESRYP | LLLPKGVVLK | LKPVATRFPR | KAWRQKRSSV | ||||
| LKPLLIQPSP | SLQPSFNPGK | TPARSTHSEA | PPSKMVLRIP | HPIQPATVLQ | ||||
| TVPGVPPLGV | SGGESFESPA | ALPAVPPEAR | TSFPLSESQT | LLSSAPVPKV | ||||
| MLPSLAPSKF | RKPYVRRRPS | KRRGVKASPC | MKPAPVIHHP | ASVIFTVPAT | ||||
| TVKIVSLGGG | CNMIQPVNAA | VAQSPQTIPI | TTLLVNPTSF | PCPLNQSLVA | ||||
| SSVSPLIVSG | NSVNLPIPST | PEDKAHVNVD | IACAVADGEN | AFQGLEPKLE | ||||
| PQELSPLSAT | VFPKVEHSPG | PPLADAECQE | GLSENSACRW | TVVKTEEGRQ | ||||
| ALEPLPQGIQ | ESLNNPTPGD | LEEIVKMEPE | EAREEISGSP | ERDICDDIKV | ||||
| EHAVELDTGA | PSEELSSAGE | VTKQTVLQKE | EERSQPTKTP | SSSQEPPDEG | ||||
| TSGTDVNKGS | SKNALSSMDP | EVRLSSPPGK | PEDSSSVDGQ | SVGTPVGPET | ||||
| GGEKNGPEEE | EEEDFDDLTQ | DEEDEMSSAS | EESVLSVPEL | QETMEKLTWL | ||||
| ASERRMSQEG | ESEEENSQEE | NSEPEEEEEE | EAEGMESLQK | EDEMTDEAVG | ||||
| DSAEKPPTFA | SPETAPEVET | SRTPPGESIK | AAGKGRNNHR | ARNKRGSRAR | ||||
| ASKDTSKLLL | LYDEDILERD | PLREQKDLAF | AQAYLTRVRE | ALQHIPGKYE | ||||
| DFLQVIYEFE | SSTQRRTAVD | LYKSLQILLQ | DWPQLLKDFA | AFLLPEQALA | ||||
| CGLFEEQQAF | EKSRKFLRQL | EICFAENPSH | HQKIIKVLQG | CADCLPQEIT | ||||
| ELKTQMWQLL | KGHDHLQDEF | SIFFDHLRPA | ASRMGDFEEI | NWTEEKEYEF | ||||
| DGFEEVALPD | VEEEEEPPKI | PTASKNKRKK | EIGVQNHDKE | TEWPDGAKDC | ||||
| ACSCHEGGPD | SKLKKSKRRS | CSHCSSKVCD | SKSYKSKEPH | ELVGSSPHRE | ||||
| ASPMPGAKEA | GQGKDMMEEE | APEERESTEA | TQSRTVRTTR | KGEMPVSAGL | ||||
| AVGSTLPSPR | EVTVTERLLL | DGPPPHSPET | PQFPPTTGAV | LYTVKRNQVG | ||||
| PEVRSCPKAS | PRLQKEREGQ | KAVSESEALM | LVWDASETEK | LPGTVEPPAS | ||||
| FLSPVSSKTR | DAGRRHVSGK | PDTQERWLPS | SRARVKTRDR | TCPVHESPSG | ||||
| IDTSETSPKA | PRGGLAKDSG | TQAKGPEGEQ | QPKAAEATVC | ANNSKVSSTG | ||||
| EKVVLWTREA | DRVILTMCQE | QGAQPQTFNI | ISQQLGNKTP | AEVSHRFREL | ||||
| MQLFHTACEA | SSEDEDDATS | TSNADQLSDH | GDLLSEEELD | E |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000116580 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054199 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Münstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (august 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
- ^ "Entrez Gene: GON4L gon-4-like (C. elegans)".
- ^ "Expasy listing: GON4L gon-4-like".
- ^ OMIM: GON4L gon-4-like -610393
- ^ "UniProt, Q3T8J9" (jezik: en.). Pristupljeno 11. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
[uredi | uredi izvor]- Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (januar 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (oktobar 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, et al. (maj 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.