HIST1H4D

HIST1H4D
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifikatori
Aliasi	H4C4
Vanjski ID-jevi	OMIM: 602823 MGI: 2448441 HomoloGene: 134478 GeneCards: H4C4
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	26,189,112 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	21,996,317 bp
Ontologija gena
Molekularna funkcija	• protein domain specific binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein heterodimerization activity; • vezivanje sa DNK; • GO:0031493 histone binding; • vezivanje sa RNK;
Ćelijska komponenta	• membrana; • hromosom; • nukleoplazma; • extracellular region; • nuclear chromosome; • Nukleosom; • Egzosom; • jedro; • GO:0005578 Vanćelijski matriks; • GO:0009327 makromolekulani kompleks;
Biološki proces	• telomere organization; • epigenetic maintenance of chromatin in transcription-competent conformation; • protein heterotetramerization; • negative regulation of megakaryocyte differentiation; • GO:0061641 CENP-A containing chromatin assembly; • GO:0034723 DNA replication-dependent chromatin assembly; • rDNA heterochromatin assembly; • negative regulation of gene expression, epigenetic; • DNA-templated transcription, initiation; • double-strand break repair via nonhomologous end joining; • beta-catenin-TCF complex assembly; • telomere capping; • nucleosome assembly; • GO:1905616 regulation of gene silencing by miRNA; • regulation of megakaryocyte differentiation; • regulation of hematopoietic stem cell differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	8360
	100041230
	ENSG00000277157
	ENSMUSG00000069306
	P62805
	P62806
	NM_003539
	NM_001195421
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4D sa hromosoma 6.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina 11.367 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSGRGKGGKG	LGKGGAKRHR	KVLRDNIQGI	TKPAIRRLAR	RGGVKRISGL
IYEETRGVLK	VFLENVIRDA	VTYTEHAKRK	TVTAMDVVYA	LKRQGRTLYG
FGG

Funkcija

Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri jezgarna histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK-linkera između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen se nalazi u velikom klasteru histonskih gena na hromosomu 6.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000277157 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069306 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b ^c "Entrez Gene: HIST1H4D histone cluster 1, H4d".