SLC10A4
Član 4 porodice rastvornih nosača 10 jest protein koji je kod ljudi kodiran genom SLC10A4 sa hromosoma 4.[5] Kod miševa, čini se da podstiče zakiseljavanje sinapsnih vezikula koje sadrže monoamine, poboljšavajući njihovo uzimanje i koeksprimira se s VMAT2 i VAChT.[6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 437 aminokiselina, а molekulska težina 46.504 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDGNDNVTLL | FAPLLRDNYT | LAPNASSLGP | GTDLALAPAS | SAGPGPGLSL | ||||
| GPGPSFGFSP | GPTPTPEPTT | SGLAGGAASH | GPSPFPRPWA | PHALPFWDTP | ||||
| LNHGLNVFVG | AALCITMLGL | GCTVDVNHFG | AHVRRPVGAL | LAALCQFGLL | ||||
| PLLAFLLALA | FKLDEVAAVA | VLLCGCCPGG | NLSNLMSLLV | DGDMNLSIIM | ||||
| TISSTLLALV | LMPLCLWIYS | WAWINTPIVQ | LLPLGTVTLT | LCSTLIPIGL | ||||
| GVFIRYKYSR | VADYIVKVSL | WSLLVTLVVL | FIMTGTMLGP | ELLASIPAAV | ||||
| YVIAIFMPLA | GYASGYGLAT | LFHLPPNCKR | TVCLETGSQN | VQLCTAILKL | ||||
| AFPPQFIGSM | YMFPLLYALF | QSAEAGIFVL | IYKMYGSEML | HKRDPLDEDE | ||||
| DTDISYKKLK | EEEMADTSYG | TVKAENIIMM | ETAQTSL |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000145248 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029219 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Solute carrier family 10 member 4". Pristupljeno 17. 4. 2016.
- ^ Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K (mart 2015). "SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis". Biological Psychiatry. 77 (6): 526–36. doi:10.1016/j.biopsych.2014.07.017. hdl:11858/00-001M-0000-0025-7742-E. PMID 25176177. S2CID 6665524.
- ^ "UniProt, Q96EP9" (jezik: engleski). Pristupljeno 30. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Splinter PL, Lazaridis KN, Dawson PA, LaRusso NF (novembar 2006). "Cloning and expression of SLC10A4, a putative organic anion transport protein". World Journal of Gastroenterology. 12 (42): 6797–805. doi:10.3748/wjg.v12.i42.6797. PMC 4087434. PMID 17106928.