SOS-kutija
SOS-kutija je regija u promotoru različitih gena za koje se LexA represor veže da potisne transkripciju proteina indukovanih SOS-om. Ovo se dešava u odsustvu oštećenja DNK. U prisustvu oštećenja DNK, vezivanje LexA je inaktivirano RecA aktivatorom. SOS kutije se razlikuju po DNK sekvencama i afinitetu vezivanja prema LexA od organizma do organizma.[1] Nadalje, SOS kutije mogu biti prisutne na dvostruki način, što ukazuje da više od jedne SOS kutije može biti unutar istog promotora.[2]
Primjeri
[uredi | uredi izvor]| Fillogenetički kladus | Sekvenca | Referenca |
|---|---|---|
| Alphaproteobacteria | GAAC(N)7GAAC GTTC(N)7GTTC | [3][4] |
| Betaproteobacteria Gammaproteobacteria | CTGT(N)8ACAG | [5] |
| Deltaproteobacteria | CTRHAMRYBYGTTCAGS | [6] |
| Gram-pozitivne bakterije | CGAACRNRYGTTYC | [7][8] |
| Cyanobacteria | RGTAC(N)3DGTWCB | [9] |
Za objašnjenje ne-GATC nukleotidnih slova, pogledajte Nomenklatura nukleinskih kiselina.
Također pogledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis". Trends in Biochemical Sciences. 20 (10): 416–20. doi:10.1016/s0968-0004(00)89091-x. PMID 8533155.
- ^ Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology. 154 (6): 1783–1792. doi:10.1099/mic.0.2007/016139-0. PMC 2729051. PMID 18524933.
- ^ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. doi:10.1046/j.1365-2958.1998.00860.x. PMID 9663685.
- ^ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. doi:10.1007/s004380051066. PMID 10503543. S2CID 2373618.
- ^ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics. 19 (17): 2225–36. doi:10.1093/bioinformatics/btg303. PMID 14630651.
- ^ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858.
- ^ Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. doi:10.1128/JB.180.8.2201-2211.1998. PMC 107149. PMID 9555905.
- ^ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. doi:10.1128/JB.184.12.3287-3295.2002. PMC 135081. PMID 12029045.
- ^ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics. 271 (1): 40–9. doi:10.1007/s00438-003-0952-x. PMID 14652736. S2CID 9219764.
- Erill I, et al. (2004). "Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics". Nucleic Acids Research. 32 (22): 6617–26. doi:10.1093/nar/gkh996. PMC 545464. PMID 15604457.
- Shinagawa H (1996). "SOS response as an adaptive response to DNA damage in prokaryotes". Stress-Inducible Cellular Responses. EXS. 77. str. 221–35. doi:10.1007/978-3-0348-9088-5_14. ISBN 978-3-0348-9901-7. PMID 8856977.