TNFAIP8L2

TNFAIP8L2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3F4M
Identifikatori
Aliasi	TNFAIP8L2
Vanjski ID-jevi	OMIM: 612112 MGI: 1917019 HomoloGene: 56998 GeneCards: TNFAIP8L2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	151,159,749 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	95,049,671 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma;
Biološki proces	• Urođeni imunski sistem; • negative regulation of T cell activation; • negative regulation of inflammatory response; • immune system process; • regulation of apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	79626
	69769
	ENSG00000163154
	ENSMUSG00000013707
	Q6P589
	Q9D8Y7
	NM_024575
	NM_027206
	NP_078851
	NP_081482
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TNF-alfa inducirani protein 8 sličan proteinu 2 (TNFAIP8L2 ili TIPE2) jest protein koji je kod ljudi kodiran genom TNFAIP8L2 sa hromosoma 1. Eksprimiran je prvenstveno u tipovima ljudskih mijeloidnih ćelija i služi kao regulator imunskee kontrolne tačke upala i metabolizma.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 184 aminokiseline, a molekulska težina 20.556 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MESFSSKSLA	LQAEKKLLSK	MAGRSVAHLF	IDETSSEVLD	ELYRVSKEYT
HSRPQAQRVI	KDLIKVAIKV	AVLHRNGSFG	PSELALATRF	RQKLRQGAMT
ALSFGEVDFT	FEAAVLAGLL	TECRDVLLEL	VEHHLTPKSH	GRIRHVFDHF
SDPGLLTALY	GPDFTQHLGK	ICDGLRKLLD	EGKL

Struktura

Kristalna struktura TIPE2 otkriva da sadrži veliku, hidrofobnu centralnu šupljinu koja je spremna za vezivanje kofaktora.^[7]

Funkcija

TNFAIP8L2 je član porodice TNFAIP8 (protein 8 izazvan faktorom nekroze tumora-α ili TIPE) koji funkcionišu kao transferni proteini za drugoglasničke lipide PIP2 i PIP3. Ostala tri člana porodice su TNFAIP8, TNFAIP8L1 i TNFAIP8L3.^[8]

Klinički značaj

TIPE2 djeluje kao negativan regulator imunskog sistema.^[5]^[9] Podreguliran je kod pacijenata sa infektivnim i autoimunskim bolestima, a djeluje i kao tumorski supresor kod nekoliko tipova raka.^[10] Njegov nokaut dovodi do leukocitoze i sistemskih upalnih poremećaja kod miševa.^[8]^[11]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163154 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013707 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Li T, Wang W, et al. (maj 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.
^ "UniProt, Q6P589" (jezik: engleski). Pristupljeno 19. 12. 2021.
^ Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y (januar 2009). "Crystal structure of TIPE2 provides insights into immune homeostasis". Nature Structural & Molecular Biology. 16 (1): 89–90. doi:10.1038/nsmb.1522. PMID 19079267. S2CID 11111978.
^ ^a ^b Goldsmith JR, Chen YH (juni 2017). "Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins". Cellular & Molecular Immunology. 14 (6): 482–487. doi:10.1038/cmi.2017.4. PMC 5719143. PMID 28287114.
^ Sun H, Gong S, et al. (2008). "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis". Cell. 133 (3): 415–26. doi:10.1016/j.cell.2008.03.026. PMC 2398615. PMID 18455983.
^ Li Z, Jia W, Niu J, Zhang L (februar 2018). "Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis". Histology and Histopathology. 33 (9): 919–928. doi:10.14670/HH-11-977. PMID 29480508.
^ Lou Y, Liu S (oktobar 2011). "The TIPE (TNFAIP8) family in inflammation, immunity, and cancer". Molecular Immunology. 49 (1–2): 4–7. doi:10.1016/j.molimm.2011.08.006. PMID 21924498.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163154 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013707 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Li_et_al_2018-5] Li T, Wang W, et al. (maj 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

[UniProt-6] "UniProt, Q6P589" (jezik: engleski). Pristupljeno 19. 12. 2021.

[pmid19079267-7] Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y (januar 2009). "Crystal structure of TIPE2 provides insights into immune homeostasis". Nature Structural & Molecular Biology. 16 (1): 89–90. doi:10.1038/nsmb.1522. PMID 19079267. S2CID 11111978.

[Goldsmith_2017-8] Goldsmith JR, Chen YH (juni 2017). "Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins". Cellular & Molecular Immunology. 14 (6): 482–487. doi:10.1038/cmi.2017.4. PMC 5719143. PMID 28287114.

[pmid18455983-9] Sun H, Gong S, et al. (2008). "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis". Cell. 133 (3): 415–26. doi:10.1016/j.cell.2008.03.026. PMC 2398615. PMID 18455983.

[Li_2018-10] Li Z, Jia W, Niu J, Zhang L (februar 2018). "Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis". Histology and Histopathology. 33 (9): 919–928. doi:10.14670/HH-11-977. PMID 29480508.

[Lou_2011-11] Lou Y, Liu S (oktobar 2011). "The TIPE (TNFAIP8) family in inflammation, immunity, and cancer". Molecular Immunology. 49 (1–2): 4–7. doi:10.1016/j.molimm.2011.08.006. PMID 21924498.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]