WARS2

WARS2
Identifikatori
Aliasi	WARS2
Vanjski ID-jevi	OMIM: 604733 MGI: 1917810 HomoloGene: 5673 GeneCards: WARS2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	119,140,654 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	99,146,502 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aminoacyl-tRNA ligase activity; • nucleotide binding; • ligase activity; • ATP binding; • tryptophan-tRNA ligase activity;
Ćelijska komponenta	• citoplazma; • mitohondrija; • ćelijska membrana; • mitochondrial matrix;
Biološki proces	• Vaskulogeneza; • tryptophanyl-tRNA aminoacylation; • tRNA aminoacylation for protein translation; • Biosinteza bjelančevina; • mitochondrial tryptophanyl-tRNA aminoacylation;
	Izvori:Amigo / QuickGO
Ortolozi
	10352
	70560
	ENSG00000116874
	ENSMUSG00000004233
	Q9UGM6
	Q9CYK1
NM_015836; NM_201263; NM_001378226; NM_001378227; NM_001378228;
	NM_001378229; NM_001378230; NM_001378231
	NM_027462
NP_056651; NP_957715; NP_001365155; NP_001365156; NP_001365157;
	NP_001365158; NP_001365159; NP_001365160
	NP_081738
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijska triptofanil-tRNK sintetaza jest enzim koji je kod ljudi kodiran genom WARS2 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 360 aminokiselina, a molekulska težina 40.147 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALHSMRKAR	ERWSFIRALH	KGSAAAPALQ	KDSKKRVFSG	IQPTGILHLG
NYLGAIESWV	RLQDEYDSVL	YSIVDLHSIT	VPQDPAVLRQ	SILDMTAVLL
ACGINPEKSI	LFQQSQVSEH	TQLSWILSCM	VRLPRLQHLH	QWKAKTTKQK
HDGTVGLLTY	PVLQAADILL	YKSTHVPVGE	DQVQHMELVQ	DLAQGFNKKY
GEFFPVPESI	LTSMKKVKSL	RDPSAKMSKS	DPDKLATVRI	TDSPEEIVQK
FRKAVTDFTS	EVTYDPAGRA	GVSNIVAVHA	AVTGLSVEEV	VRRSAGMNTA
RYKLAVADAV	IEKFAPIKRE	IEKLKLDKDH	LEKVLQIGSA	KAKELAYTVC
QEVKKLVGFL

Funkcija

Aminoacil-tRNK sintetaze kataliziraju aminoacilaciju tRNK pomoću njihove srodne aminokiseline. Zbog njihove centralne uloge u povezivanju aminokiselina sa nukleotidnim tripletnim sadržanim u tRNK, smatra se da su aminoacil-tRNK sintetaze među prvim proteinima koji su se pojavili u evoluciji. Postoje dva oblika triptofanil-tRNK sintetaze, citoplazmatski, zvani WARS i mitohondrijski oblik, zvani WARS2. Ovaj gen kodira mitohondrijsku triptofanil-tRNK sintetazu. Opisane su dije alternativne varijante transkripta koje kodiraju različite izoforme].^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116874 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004233 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (Mar 1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3→p13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 249–50. doi:10.1159/000015196. PMID 10072595. S2CID 28931531.
^ Jorgensen R, Søgaard TM, Rossing AB, Martensen PM, Justesen J (Jul 2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase". J Biol Chem. 275 (22): 16820–6. doi:10.1074/jbc.275.22.16820. PMID 10828066.
^ ^a ^b "Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial".
^ "UniProt, Q9UGM6" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMC 373357. PMID 14757836.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Guo LT, Chen XL, Zhao BT, Shi Y, Li W, Xue H, Jin YX (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMC 2034488. PMID 17726052.

Vanjski linkovi

WARS2 lokacija ljudskog genoma UCSC Genome Browser.

WARS2 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116874 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004233 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072595-5] Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (Mar 1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3→p13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 249–50. doi:10.1159/000015196. PMID 10072595. S2CID 28931531.

[pmid10828066-6] Jorgensen R, Søgaard TM, Rossing AB, Martensen PM, Justesen J (Jul 2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase". J Biol Chem. 275 (22): 16820–6. doi:10.1074/jbc.275.22.16820. PMID 10828066.

[entrez-7] "Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial".

[UniProt-8] "UniProt, Q9UGM6" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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