Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[5][6][7]
The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[5][6]
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[7][8] Its suppressive role on melanoma development has been reported recently.[9]
^Gagnon KB, England R, Diehl L, Delpire E (May 2007). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". American Journal of Physiology. Cell Physiology. 292 (5): C1809–C1815. doi:10.1152/ajpcell.00580.2006. PMID17267545. S2CID10258460.
Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, Yano R (Apr 2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain". Brain Research. Molecular Brain Research. 112 (1–2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID12670708.
Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, Hisanaga S (Oct 2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein". Biochemical and Biophysical Research Communications. 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID14521924.
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