Protein-coding gene in the species Homo sapiens
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene .[5]
Function [ edit ] The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene . It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[6]
Clinical significance [ edit ] BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer 's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[7]
Interactions [ edit ] BAG1 has been shown to interact with:
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000107262 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028416 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (March 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity" . Cell . 80 (2): 279–84. doi :10.1016/0092-8674(95)90410-7 PMID 7834747 . S2CID 17824475 . ^ "Entrez Gene: BAG1 BCL2-associated athanogene" .^ Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009). "Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3" . EMBO J . 28 (7): 889–901. doi :10.1038/emboj.2009.29 . PMC 2647772 PMID 19229298 . "Old Cells Work Differently" . Phys.org . March 1, 2009.^ Shatkina L, Mink S, Rogatsch H, Klocker H, Langer G, Nestl A, Cato AC (October 2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor" . Mol. Cell. Biol . 23 (20): 7189–97. doi :10.1128/mcb.23.20.7189-7197.2003 . PMC 230325 PMID 14517289 . ^ Knee DA, Froesch BA, Nuber U, Takayama S, Reed JC (April 2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity" . J. Biol. Chem . 276 (16): 12718–24. doi :10.1074/jbc.M010841200 PMID 11278763 . ^ Froesch BA, Takayama S, Reed JC (May 1998). "BAG-1L protein enhances androgen receptor function" . J. Biol. Chem . 273 (19): 11660–6. doi :10.1074/jbc.273.19.11660 PMID 9565586 . ^ Wang HG, Takayama S, Rapp UR, Reed JC (July 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1" . Proc. Natl. Acad. Sci. U.S.A . 93 (14): 7063–8. Bibcode :1996PNAS...93.7063W . doi :10.1073/pnas.93.14.7063 PMC 38936 PMID 8692945 . ^ Guzey M, Takayama S, Reed JC (Dec 2000). "BAG1L enhances trans-activation function of the vitamin D receptor" . J. Biol. Chem . 275 (52): 40749–56. doi :10.1074/jbc.M004977200 PMID 10967105 . ^ Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato AC (June 1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis" . J. Biol. Chem . 273 (23): 14620–5. doi :10.1074/jbc.273.23.14620 PMID 9603979 . ^ Schneikert J, Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato AC (Dec 2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor" . EMBO J . 19 (23): 6508–16. doi :10.1093/emboj/19.23.6508 . PMC 305849 PMID 11101523 . ^ Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC (August 1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70" . EMBO J . 16 (16): 4887–96. doi :10.1093/emboj/16.16.4887 . PMC 1170124 PMID 9305631 . ^ Takayama S, Xie Z, Reed JC (January 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators" . J. Biol. Chem . 274 (2): 781–6. doi :10.1074/jbc.274.2.781 PMID 9873016 . ^ Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR (August 2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation" . J. Biol. Chem . 276 (32): 30127–32. doi :10.1074/jbc.M010237200 PMID 11340068 . ^ Hung WJ, Roberson RS, Taft J, Wu DY (May 2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions" . Mol. Cell. Biol . 23 (10): 3477–86. doi :10.1128/mcb.23.10.3477-3486.2003 . PMC 164759 PMID 12724406 . ^ Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK (July 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells" . J. Biol. Chem . 273 (27): 16985–92. doi :10.1074/jbc.273.27.16985 PMID 9642262 . ^ Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC (May 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1" . EMBO J . 17 (10): 2736–47. doi :10.1093/emboj/17.10.2736 . PMC 1170614 PMID 9582267 . External links [ edit ] Further reading [ edit ] Tang SC (2003). "BAG-1, an anti-apoptotic tumour marker" . IUBMB Life . 53 (2): 99–105. doi :10.1080/15216540211473 PMID 12049201 . S2CID 8704191 . Clemo NK, Arhel NJ, Barnes JD, et al. (2005). "The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival". Biochem. Soc. Trans . 33 (Pt 4): 676–8. doi :10.1042/BST0330676 . PMID 16042572 . Gehring U (2007). "Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms" . Cell Stress & Chaperones . 11 (4): 295–303. doi :10.1379/1466-1268(2006)11[295:aotcba]2.0.co;2 . PMC 1712677 PMID 17278878 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Zeiner M, Gehring U (1996). "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 92 (25): 11465–9. doi :10.1073/pnas.92.25.11465 PMC 40422 PMID 8524784 . Wang HG, Takayama S, Rapp UR, Reed JC (1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1" . Proc. Natl. Acad. Sci. U.S.A . 93 (14): 7063–8. Bibcode :1996PNAS...93.7063W . doi :10.1073/pnas.93.14.7063 PMC 38936 PMID 8692945 . Takayama S, Kochel K, Irie S, et al. (1996). "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12" . Genomics . 35 (3): 494–8. doi :10.1006/geno.1996.0389 PMID 8812483 . Bardelli A , Longati P, Albero D, et al. (1997). "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death" . EMBO J . 15 (22): 6205–12. doi :10.1002/j.1460-2075.1996.tb01009.x . PMC 452442 PMID 8947043 .Takayama S, Bimston DN, Matsuzawa S, et al. (1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70" . EMBO J . 16 (16): 4887–96. doi :10.1093/emboj/16.16.4887 . PMC 1170124 PMID 9305631 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Packham G, Brimmell M, Cleveland JL (1998). "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation" . Biochem. J . 328. ( Pt 3) (3): 807–13. doi :10.1042/bj3280807 . PMC 1218990 PMID 9396724 . Matsuzawa S, Takayama S, Froesch BA, et al. (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1" . EMBO J . 17 (10): 2736–47. doi :10.1093/emboj/17.10.2736 . PMC 1170614 PMID 9582267 . Kullmann M, Schneikert J, Moll J, et al. (1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis" . J. Biol. Chem . 273 (23): 14620–5. doi :10.1074/jbc.273.23.14620 PMID 9603979 . Liu R, Takayama S, Zheng Y, et al. (1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells" . J. Biol. Chem . 273 (27): 16985–92. doi :10.1074/jbc.273.27.16985 PMID 9642262 . Takayama S, Krajewski S, Krajewska M, et al. (1998). "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines". Cancer Res . 58 (14): 3116–31. PMID 9679980 . Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators" . J. Biol. Chem . 274 (2): 781–6. doi :10.1074/jbc.274.2.781 PMID 9873016 . Yang X, Pater A, Tang SC (1999). "Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants" . Oncogene . 18 (32): 4546–53. doi :10.1038/sj.onc.1202843 PMID 10467399 . Schneikert J, Hübner S, Martin E, Cato AC (1999). "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity" . J. Cell Biol . 146 (5): 929–40. doi :10.1083/jcb.146.5.929 . PMC 2169481 PMID 10477749 . Lüders J, Demand J, Höhfeld J (2000). "The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome" . J. Biol. Chem . 275 (7): 4613–7. doi :10.1074/jbc.275.7.4613 PMID 10671488 .
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