CD180

CD180
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B2D
Identifiers
Aliases	CD180, LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Gene location (Human)
Chr.	Chromosome 5 (human)
End	67,196,799 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	102,876,137 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; lymph node; ; monocyte; ; spleen; ; appendix; ; bone marrow cells; ; blood; ; superficial temporal artery; ; spongy bone; ; thymus;
	Top expressed in
	secondary oocyte; ; spleen; ; right ventricle; ; blood; ; thymus; ; lip; ; bone marrow; ; tracheobronchial tree; ; trachea; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; extracellular space; extracellular matrix;
Biological process	positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; cellular response to lipopolysaccharide; B cell proliferation involved in immune response; immune system process; toll-like receptor signaling pathway; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4064
	17079
	ENSG00000134061
	ENSMUSG00000021624
	Q99467
	Q62192
	NM_005582
	NM_008533; NM_001360519
	NP_005573
	NP_032559; NP_001347448
	Wikidata
View/Edit Human	View/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene.^[5]^[6]^[7]^[8]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.^[7]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.^[9]^[10]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021624 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. doi:10.1182/blood.V92.8.2815. PMID 9763566.
^ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.
^ ^a ^b "Entrez Gene: CD180 CD180 molecule".
^ ^[permanent dead link] [4]
^ Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, Nathwani A, Damle RN, Chiorazzi N, Lydyard PM (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749. S2CID 13360804.
^ Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, Sidorenko SP (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. Bibcode:2017PLoSO..1285940G. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

External links[edit]

Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q99467 (Human CD180 antigen) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q62192 (Mouse CD180 antigen) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021624 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9763566-5] Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. doi:10.1182/blood.V92.8.2815. PMID 9763566.

[pmid8975706-6] Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.

[entrez-7] "Entrez Gene: CD180 CD180 molecule".

[8] [permanent dead link] [4]

[9] Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, Nathwani A, Damle RN, Chiorazzi N, Lydyard PM (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749. S2CID 13360804.

[10] Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, Sidorenko SP (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. Bibcode:2017PLoSO..1285940G. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

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CD180

References[edit]

Further reading[edit]

External links[edit]

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