CD52

CD52
Identifiers
Aliases	CD52, CDW52, CD52 molecule, EDDM5, HE5
External IDs	OMIM: 114280 HomoloGene: 88652 GeneCards: CD52
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,320,523 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; monocyte; ; spleen; ; thymus; ; right lung; ; lymph node; ; appendix; ; blood; ; upper lobe of left lung; ; gallbladder;
	n/a
	More reference expression data
	n/a
Orthologs
	1043
	n/a
	ENSG00000169442
	n/a
	P31358
	n/a
	NM_001803
	n/a
	NP_001794
	n/a
	Wikidata
View/Edit Human

CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.

CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes^[3] and dendritic cells.^[4] Further, it is found within the male genital tract and is present on the surface of mature sperm cells.

CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.^[5]

CD52 binds the ITIM (immunoreceptor tyrosine-based inhibitory motif)-bearing sialic acid-binding lectin SIGLEC10.

Clinical significance[edit]

It is associated with certain types of lymphoma.^[6]

It is the protein targeted by alemtuzumab, a monoclonal antibody used for the treatment of chronic lymphocytic leukemia and organ transplantation. A phase III trial into treatment of relapsing-remitting multiple sclerosis showed a reduction in relapse rate, but no statistically significant reduction in accumulated disability, when used as a first-line therapy.^[7] However, a sister study looking at patients in whom relapses had occurred despite treatment with interferon beta or glatiramer demonstrated reduction in both relapse rate and accumulated disability. 20% patients randomised to interferon beta 1a had "sustained accumulation of disability" compared with 13% in the alemtuzumab group.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169442 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): 1715–20. doi:10.1182/blood.V100.5.1715.h81702001715_1715_1720. PMID 12176892.
^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood. 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.
^ Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. ISBN 978-1-59259-076-6. PMID 21337094.
^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (April 2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica. 92 (4): 566–7. doi:10.3324/haematol.10767. hdl:11585/51398. PMID 17488672.
^ Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA (November 2012). "Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial". Lancet. 380 (9856): 1829–39. doi:10.1016/S0140-6736(12)61768-1. PMID 23122650. S2CID 5736696.^{[unreliable medical source?]}
^ Cohen, Jeffrey; Coles A; Arnold D (24 November 2012). "Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial". The Lancet. 380 (9856): 1819–1828. doi:10.1016/S0140-6736(12)61769-3. PMID 23122652. S2CID 15841906. Retrieved 28 December 2012.

External links[edit]

CD52+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD52 genome location and CD52 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169442 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12176892-3] Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): 1715–20. doi:10.1182/blood.V100.5.1715.h81702001715_1715_1720. PMID 12176892.

[pmid12393688-4] Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood. 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.

[pmid21337094-5] Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. ISBN 978-1-59259-076-6. PMID 21337094.

[pmid17488672-6] Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (April 2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica. 92 (4): 566–7. doi:10.3324/haematol.10767. hdl:11585/51398. PMID 17488672.

[Coles_2012-7] Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA (November 2012). "Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial". Lancet. 380 (9856): 1829–39. doi:10.1016/S0140-6736(12)61768-1. PMID 23122650. S2CID 5736696.^{[unreliable medical source?]}

[8] Cohen, Jeffrey; Coles A; Arnold D (24 November 2012). "Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial". The Lancet. 380 (9856): 1819–1828. doi:10.1016/S0140-6736(12)61769-3. PMID 23122652. S2CID 15841906. Retrieved 28 December 2012.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD52

Clinical significance[edit]

References[edit]

External links[edit]

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