CD6

CD6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A2E
Identifiers
Aliases	CD6, TP120, CD6 molecule
External IDs	OMIM: 186720 MGI: 103566 HomoloGene: 4893 GeneCards: CD6
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,020,377 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,807,422 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; thymus; ; appendix; ; spleen; ; cervix epithelium; ; superficial temporal artery; ; bone marrow; ; endothelial cell; ; bone marrow cells;
	Top expressed in
	thymus; ; blood; ; axillary lymph node; ; subcutaneous adipose tissue; ; spleen; ; morula; ; entorhinal cortex; ; visual cortex; ; jejunum; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipopolysaccharide binding; lipoteichoic acid binding; scavenger receptor activity; protein binding; identical protein binding;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex; extracellular region; immunological synapse; external side of plasma membrane;
Biological process	positive regulation of cytokine production involved in inflammatory response; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; adaptive immune response; immune system process; acute inflammatory response to antigenic stimulus; receptor-mediated endocytosis; response to lipopolysaccharide; cell adhesion; positive regulation of T cell proliferation; innate immune response; immunological synapse formation; lipopolysaccharide-mediated signaling pathway; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	923
	12511
	ENSG00000013725
	ENSMUSG00000024670
	P30203
	Q61003
	NM_001254750; NM_001254751; NM_006725
	NM_001037801; NM_009852
	NP_001241679; NP_001241680; NP_006716
	NP_001032890; NP_033982
	Wikidata
View/Edit Human	View/Edit Mouse

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.^[5]^[6]

Function[edit]

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.^[5]

Clinical significance[edit]

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.^[7]^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD6 CD6 molecule".
^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
^ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648. PMID 19525953.
^ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685.

Further reading[edit]

Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. doi:10.1084/jem.174.4.949. PMC 2118957. PMID 1919444.
Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. doi:10.1016/S0021-9258(20)89621-5. PMID 2016320.
Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. doi:10.1007/BF01534678. PMID 3923629. S2CID 39343360.
Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. doi:10.1074/jbc.270.31.18187. PMID 7543097.
Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. doi:10.1002/eji.1830251008. PMID 7589069. S2CID 8996113.
Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. doi:10.1084/jem.177.1.219. PMC 2190871. PMID 7678115.
Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. doi:10.4049/jimmunol.158.3.1149. PMID 9013954. S2CID 24196035.
Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. doi:10.1002/eji.1830271133. PMID 9394826. S2CID 20897222.
Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. doi:10.1016/S0165-2478(97)02707-7. PMID 9436462.
Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. doi:10.1074/jbc.M209591200. PMID 12473675.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Gimferrer I, Ibáñez A, Farnós M, Sarrias MR, Fenutría R, Roselló S, Zimmermann P, David G, Vives J, Serra-Pagès C, Lozano F (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. doi:10.4049/jimmunol.175.3.1406. PMID 16034076.
Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. doi:10.4049/jimmunol.177.2.877. PMID 16818742.
Ibáñez A, Sarrias MR, Farnós M, Gimferrer I, Serra-Pagès C, Vives J, Lozano F (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. doi:10.4049/jimmunol.177.2.1152. PMID 16818773.
Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. doi:10.1128/MCB.00688-06. PMC 1592849. PMID 16914752.
Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. doi:10.4049/jimmunol.178.7.4351. PMID 17371992.
Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. Bibcode:2007PNAS..10411724S. doi:10.1073/pnas.0702815104. PMC 1913855. PMID 17601777.

External links[edit]

CD6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD6 CD6 molecule".

[pmid7760007-6] Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.

[pmid19525953-7] De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648. PMID 19525953.

[pmid21849685-8] Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD6

Function[edit]

Clinical significance[edit]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

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