Chlorohydroxyphenylglycine
From Wikipedia the free encyclopedia
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| Names | |
|---|---|
| IUPAC name Amino(2-chloro-5-hydroxyphenyl)acetic acid | |
| Identifiers | |
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3D model (JSmol) | |
| Abbreviations | CHPG |
| ChemSpider | |
| ECHA InfoCard | 100.162.133 |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
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| Properties | |
| C8H6ClNO3 | |
| Molar mass | 199.59 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]
It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]
References[edit]
- ^ Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology. 12: 6. doi:10.1186/1471-2210-12-6. PMC 3416681. PMID 22642439.
- ^ Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G.; Irvine M.; Costa, Blaise M.; Monaghan, Daniel T.; Bortolotto, Zuner A.; Molnár, Elek; Lodge, David; Jane, David E. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology. 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMC 4696548. PMID 22796429.
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