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|A young boy coughing due to pertussis causing whooping cough.|
A cough is a sudden expulsion of air through the large breathing passages which can help clear them of fluids, irritants, foreign particles and microbes. As a protective reflex, coughing can be repetitive with the cough reflex following three phases: an inhalation, a forced exhalation against a closed glottis, and a violent release of air from the lungs following opening of the glottis, usually accompanied by a distinctive sound.
Frequent coughing usually indicates the presence of a disease. Many viruses and bacteria benefit, from an evolutionary perspective, by causing the host to cough, which helps to spread the disease to new hosts. Most of the time, irregular coughing is caused by a respiratory tract infection but can also be triggered by choking, smoking, air pollution, asthma, gastroesophageal reflux disease, post-nasal drip, chronic bronchitis, lung tumors, heart failure and medications such as angiotensin-converting-enzyme inhibitors (ACE inhibitors) and beta blockers.
Treatment should target the cause; for example, smoking cessation or discontinuing ACE inhibitors. Cough suppressants such as codeine or dextromethorphan are frequently prescribed, but have been demonstrated to have little effect. Other treatment options may target airway inflammation or may promote mucus expectoration. As it is a natural protective reflex, suppressing the cough reflex might have damaging effects, especially if the cough is productive.
The complications of coughing can be classified as either acute or chronic. Acute complications include cough syncope (fainting spells due to decreased blood flow to the brain when coughs are prolonged and forceful), insomnia, cough-induced vomiting, subconjunctival hemorrhage or "red eye", coughing defecation and in women with a prolapsed uterus, cough urination. Chronic complications are common and include abdominal or pelvic hernias, fatigue fractures of lower ribs and costochondritis. Chronic or violent coughing can contribute to damage to the pelvic floor and a possible cystocele.
A cough in children may be either a normal physiological reflex or due to an underlying cause. In healthy children it may be normal in the absence of any disease to cough ten times a day. The most common cause of an acute or subacute cough is a viral respiratory tract infection. A healthy adult also coughs 18.8 times a day on average, but in the population with respiratory disease the geometric mean frequency is 275 times a day. In adults with a chronic cough, i.e. a cough longer than 8 weeks, more than 90% of cases are due to post-nasal drip, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease. The causes of chronic cough are similar in children with the addition of bacterial bronchitis.
A cough can be the result of a respiratory tract infection such as the common cold, COVID-19, acute bronchitis, pneumonia, pertussis, or tuberculosis. In the vast majority of cases, acute coughs, i.e. coughs shorter than 3 weeks, are due to the common cold. In people with a normal chest X-ray, tuberculosis is a rare finding. Pertussis is increasingly being recognised as a cause of troublesome coughing in adults.
After a respiratory tract infection has cleared, the person may be left with a postinfectious cough. This typically is a dry, non-productive cough that produces no phlegm. Symptoms may include a tightness in the chest, and a tickle in the throat. This cough may often persist for weeks after an illness. The cause of the cough may be inflammation similar to that observed in repetitive stress disorders such as carpal tunnel syndrome. The repetition of coughing produces inflammation which produces discomfort, which in turn produces more coughing. Postinfectious cough typically does not respond to conventional cough treatments. Medication used for postinfectious coughs may include ipratropium  to treat the inflammation, as well as cough suppressants to reduce frequency of the cough until inflammation clears. Inflammation may increase sensitivity to other existing issues such as allergies, and treatment of other causes of coughs (such as use of an air purifier or allergy medicines) may help speed recovery.
Reactive airway disease
When coughing is the only complaint of a person who meets the criteria for asthma (bronchial hyperresponsiveness and reversibility), this is termed cough-variant asthma. Atopic cough and eosinophilic bronchitis are related conditions. Atopic cough occurs in individuals with a family history of atopy (an allergic condition), abundant eosinophils in the sputum, but with normal airway function and responsiveness. Eosinophilic bronchitis is characterized by eosinophils in sputum and in bronchoalveolar lavage fluid without airway hyperresponsiveness or an atopic background. This condition responds to treatment with corticosteroids. Cough can also worsen in an acute exacerbation of chronic obstructive pulmonary disease.
Asthma is a common cause of chronic cough in adults and children. Coughing may be the only symptom the person has from their asthma, or asthma symptoms may also include wheezing, shortness of breath, and a tight feeling in their chest. Depending on how severe the asthma is, it can be treated with bronchodilators (medicine which causes the airways to open up) or inhaled steroids. Treatment of the asthma should make the cough go away.
Chronic bronchitis is defined clinically as a persistent cough that produces sputum (phlegm) and mucus, for at least three months in two consecutive years. Chronic bronchitis is often the cause of "smoker's cough". The tobacco smoke causes inflammation, secretion of mucus into the airway, and difficulty clearing that mucus out of the airways. Coughing helps clear those secretions out. May be treated by quitting smoking. May also be caused by pneumoconiosis and long-term fume inhalation.
In people with unexplained cough, gastroesophageal reflux disease should be considered. This occurs when acidic contents of the stomach come back up into the esophagus. Symptoms usually associated with GERD include heartburn, sour taste in the mouth, or a feeling of acid reflux in the chest, although, more than half of the people with cough from GERD do not have any other symptoms. An esophageal pH monitor can confirm the diagnosis of GERD. Sometimes GERD can complicate respiratory ailments related to cough, such as asthma or bronchitis. The treatment involves anti-acid medications and lifestyle changes with surgery indicated in cases not manageable with conservative measures.
Coughing may be caused by air pollution including tobacco smoke, particulate matter, irritant gases, and dampness in a home. The human health effects of poor air quality are far reaching, but principally affect the body's respiratory system and the cardiovascular system. Individual reactions to air pollutants depend on the type of pollutant a person is exposed to, the degree of exposure, the individual's health status and genetics. People who exercise outdoors on hot, smoggy days, for example, increase their exposure to pollutants in the air.
A foreign body can sometimes be suspected, for example if the cough started suddenly when the patient was eating. Rarely, sutures left behind inside the airway branches can cause coughing. A cough can be triggered by dryness from mouth breathing or recurrent aspiration of food into the windpipe in people with swallowing difficulties.
Drugs used for treatments other than coughs, such as ACE inhibitors which are often used to treat high blood pressure, can sometimes cause cough as a side effect, and stopping their use will stop the cough. Beta blockers similarly cause cough as an adverse event. 
A tic cough, previously called a habit cough, is one that responds to behavioral or psychiatric therapy after organic causes have been excluded. Absence of the cough during sleep is common, but not diagnostic. A tic cough is thought to be more common in children than in adults. A similar disorder is the somatic cough syndrome previously called the psychogenic cough.
Some cases of chronic cough may be attributed to a sensory neuropathic disorder. Treatment for neurogenic cough may include the use of certain neuralgia medications. Coughing may occur in tic disorders such as Tourette syndrome, although it should be distinguished from throat-clearing in this disorder.
Cough may also be caused by conditions affecting the lung tissue such as bronchiectasis, cystic fibrosis, interstitial lung diseases and sarcoidosis. Coughing can also be triggered by benign or malignant lung tumors or mediastinal masses. Through irritation of the nerve, diseases of the external auditory canal (wax, for example) can also cause cough. Cardiovascular diseases associated with cough are heart failure, pulmonary infarction and aortic aneurysm. Nocturnal cough is associated with heart failure, as the heart does not compensate for the increased volume shift to the pulmonary circulation, in turn causing pulmonary edema and resultant cough. Other causes of nocturnal cough include asthma, post-nasal drip and gastroesophageal reflux disease (GERD). Another cause of cough occurring preferentially in supine position is recurrent aspiration.
Given its irritant nature to mammal tissues, capsaicin is widely used to determine the cough threshold and as a tussive stimulant in clinical research of cough suppressants. Capsaicin is what makes chili peppers spicy, and might explain why workers in factories with these fruits can develop a cough.
Coughing may also be used for social reasons, and as such is not always involuntary. A voluntary cough, often written as "ahem", can be used to attract attention or express displeasure, as a form of nonverbal, paralingual metacommunication.
A cough is a protective reflex in healthy individuals which is influenced by psychological factors. The cough reflex is initiated by stimulation of two different classes of afferent nerves, namely the myelinated rapidly adapting receptors, and nonmyelinated C-fibers with endings in the lung.
The type of cough may help in the diagnosis. For instance, an inspiratory "whooping" sound on coughing almost doubles the likelihood that the illness is pertussis.
A cough can be classified by its duration, character, quality, and timing. The duration can be either acute (of sudden onset) if it is present less than three weeks, subacute if it is present between three or eight weeks, and chronic when lasting longer than eight weeks. A cough can be non-productive (dry) or productive (when phlegm is produced that may be coughed up as sputum). It may occur only at night (then called nocturnal cough), during both night and day, or just during the day.
A number of characteristic coughs exist. While these have not been found to be diagnostically useful in adults, they are of use in children. A barky cough is part of the common presentation of croup. A staccato cough has been classically described with neonatal chlamydial pneumonia.
This section is missing information about treatment in adults.(December 2018)
The treatment of a cough in children is based on the underlying cause. In children half of cases go away without treatment in 10 days and 90% in 25 days.
According to the American Academy of Pediatrics the use of cough medicine to relieve cough symptoms is supported by little evidence and thus not recommended for treating cough symptoms in children. There is tentative evidence that the use of honey is better than no treatment or diphenhydramine in decreasing coughing. It does not alleviate coughing to the same extent as dextromethorphan but it shortens the cough duration better than placebo and salbutamol. A trial of antibiotics or inhaled corticosteroids may be tried in children with a chronic cough in an attempt to treat protracted bacterial bronchitis or asthma respectively. There is insufficient evidence to recommend treating children who have a cough that is not related to a specific condition with inhaled anti-cholinergics.
Because coughing can spread disease through infectious aerosol droplets, it is recommended to cover one's mouth and nose with the forearm, the inside of the elbow, a tissue or a handkerchief while coughing.
Marine mammals such as dolphins and whales cannot cough. Some invertebrates such as insects and spiders cannot cough or sneeze. Domestic animals and vertebrates such as dogs and cats can cough, because of diseases, allergies, dust or choking. In particular, cats are known for coughing before spitting up a hairball.
- Chung KF, Pavord ID (April 2008). "Prevalence, pathogenesis, and causes of chronic cough". Lancet. 371 (9621): 1364–1374. doi:10.1016/S0140-6736(08)60595-4. PMID 18424325. S2CID 7810980.
- Guidelines, Therapeutic (2021). Cough. Therapeutic Guidelines Ltd.
- Pavord ID, Chung KF (April 2008). "Management of chronic cough". Lancet. 371 (9621): 1375–1384. doi:10.1016/S0140-6736(08)60596-6. PMID 18424326. S2CID 30806409.
- "Cystocele (Prolapsed Bladder) | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2017-12-02.
- Goldsobel AB, Chipps BE (March 2010). "Cough in the pediatric population". J. Pediatr. 156 (3): 352–358.e1. doi:10.1016/j.jpeds.2009.12.004. PMID 20176183.
- Nadia, Yousaf; Monteiro, William; Matos, Sergio; Birring, Surinder S.; Pavord, Ian D. (2013). "Cough frequency in health and disease". European Respiratory Journal. 41 (1): 241–243. doi:10.1183/09031936.00089312. PMID 23277523.
- Dicpinigaitis PV, Colice GL, Goolsby MJ, Rogg GI, Spector SL, Winther B (2009). "Acute cough: a diagnostic and therapeutic challenge". Cough. 5: 11. doi:10.1186/1745-9974-5-11. PMC 2802352. PMID 20015366.
In the vast majority of cases, acute cough is due to acute viral upper respiratory tract infection (URTI), i.e., the common cold.
- Braman SS (January 2006). "Postinfectious cough: ACCP evidence-based clinical practice guidelines". Chest. 129 (1 Suppl): 138S–146S. doi:10.1378/chest.129.1_suppl.138S. PMID 16428703.
- "Cystic fibrosis - Diagnosis and treatment - Mayo Clinic". www.mayoclinic.org. Retrieved 2022-05-24.
- "UpToDate". www.uptodate.com. Retrieved 2022-05-24.
- Niimi, A (February 2011). "Cough and Asthma". Current Respiratory Medicine Reviews. 7 (1): 47–54. doi:10.2174/157339811794109327. PMC 3182093. PMID 22081767.
- "Cough". Mayo Clinic. Retrieved 2022-03-27.
- "Why You Cough". WebMD. Retrieved 2022-03-27.
- Dicpinigaitis PV (January 2006). "Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines". Chest. 129 (1 Suppl): 169S–173S. doi:10.1378/chest.129.1_suppl.169S. PMID 16428706.
- Irwin RS, Glomb WB, Chang AB (January 2006). "Habit cough, tic cough, and psychogenic cough in adult and pediatric populations: ACCP evidence-based clinical practice guidelines". Chest. 129 (1 Suppl): 174S–179S. doi:10.1378/chest.129.1_suppl.174S. PMID 16428707.
- Gibson PG, Ryan NM (August 2011). "Cough pharmacotherapy: current and future status". Expert Opinion on Pharmacotherapy. 12 (11): 1745–1755. doi:10.1517/14656566.2011.576249. PMID 21524236. S2CID 24560981.
- NCBI » Bookshelf » Clinical Methods » The Pulmonary System » Cough and Sputum Production By Sattar Farzan. Extracted from the book Clinical Methods, 3rd edition The History, Physical, and Laboratory Examinations. Edited by H Kenneth Walker, MD, W Dallas Hall, MD, and J Willis Hurst, MD. Boston: Butterworths; 1990. ISBN 0-409-90077-X
- "C.Chronic Cough". Archived from the original on 2010-10-01. Retrieved 2010-10-10. National Lung Health Education Program > C. Chronic Cough] The Snowdrift Pulmonary Foundation, Inc. 2000. ISBN 0-9671809-2-9
- "ahem". Onomatopoeia List. August 10, 2013. Archived from the original on April 4, 2023. Retrieved April 11, 2022.
- Nänny, Max; Fischer, Olga (1999). Form Miming Meaning: Iconicity in Language and Literature. John Benjamins Publishing. ISBN 9789027221797. Retrieved 25 July 2019.
- Mazzone, Stuart B.; Undem, Bradley J. (2016-07-01). "Vagal Afferent Innervation of the Airways in Health and Disease". Physiological Reviews. 96 (3): 975–1024. doi:10.1152/physrev.00039.2015. ISSN 0031-9333. PMC 4982036. PMID 27279650.
- Noah Lechtzin. "Cough in Adults". Merck Manuals. Retrieved 2017-04-07. Last full review/revision July 2016
- Bjornson CL, Johnson DW (July 2007). "Croup in the paediatric emergency department". Paediatr Child Health. 12 (6): 473–477. doi:10.1093/pch/12.6.473. PMC 2528757. PMID 19030411.
- Miller KE (April 2006). "Diagnosis and treatment of Chlamydia trachomatis infection". Am Fam Physician. 73 (8): 1411–6. PMID 16669564.
- Thompson, M.; Vodicka, T. A.; Blair, P. S.; Buckley, D. I.; Heneghan, C.; Hay, A. D. (11 December 2013). "Duration of symptoms of respiratory tract infections in children: systematic review". BMJ. 347 (dec11 1): f7027. doi:10.1136/bmj.f7027. PMC 3898587. PMID 24335668.
- Oduwole, O; Udoh, EE; Oyo-Ita, A; Meremikwu, MM (10 April 2018). "Honey for acute cough in children". The Cochrane Database of Systematic Reviews. 4 (12): CD007094. doi:10.1002/14651858.CD007094.pub5. PMC 6513626. PMID 29633783.
- Chang, A. B.; McKean, M.; Morris, P. (2004). "Inhaled anti-cholinergics for prolonged non-specific cough in children". The Cochrane Database of Systematic Reviews. 2003 (1): CD004358. doi:10.1002/14651858.CD004358.pub2. ISSN 1469-493X. PMC 8823516. PMID 14974067.
- "Coughing and Sneezing". US Centers for Disease Control and Prevention. 2020-04-24. Retrieved 2020-09-14.
- Woodard, James C.; Zam, Stephen G.; Caldwell, David K.; Caldwell, Melba C. (29 August 2016). "Some Parasitic Diseases of Dolphins". Pathologia Veterinaria. 6 (3): 257–272. doi:10.1177/030098586900600307. PMID 5817449. S2CID 26842976.
- "Is It Normal for Cats To Cough?". Pet Health Network. Retrieved 2018-04-23.
- "Coughing in horses explained". Your Horse Magazine. Archived from the original on 2020-07-28. Retrieved 2018-04-23.
- Pyziel, Anna M.; Laskowski, Zdzisław; Demiaszkiewicz, Aleksander W.; Höglund, Johan (2017). "Interrelationships of Dictyocaulusspp. In Wild Ruminants with Morphological Description of Dictyocaulus cervin. Sp. (Nematoda: Trichostrongyloidea) from Red Deer,Cervus elaphus". Journal of Parasitology. 103 (5): 506–518. doi:10.1645/16-75. PMID 28585897. S2CID 25720548.
As of this edit, this article uses content from "Acute cough: a diagnostic and therapeutic challenge", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.
- Carroll, Thomas L., ed. (2019). Chronic Cough. Plural Publishing. ISBN 9781635500707. LCCN 2018055141.