List of immunofluorescence findings for autoimmune bullous conditions
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Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.
Cutaneous conditions with positive direct or indirect immunofluorescence when using salt-split skin include:
| Condition | Antibody isotype(s) deposited | Localization of antibody with use of salt-split skin |
|---|---|---|
| Antiepilegrin cicatricial pemphigoid | IgG | Dermal |
| Bullous lupus erythematosus | Dermal | |
| Bullous pemphigoid | IgG | Epidermal |
| Cicatricial pemphigoid | IgG | Epidermal |
| Epidermolysis bullosa acquisita | IgG | Dermal |
| Linear IgA bullous dermatosis | IgA | Epidermal |
| Orf-induced immunobullous disease | IgG | Dermal |
| Pemphigoid gestationis | IgG | Epidermal |
For several subtypes of pemphigus a variety of substrates are used for indirect immunofluorescence:
| Pemphigus variant | Substrate |
|---|---|
| Pemphigus foliaceous | Guinea pig esophagus |
| Pemphigus vulgaris | Monkey esophagus |
| IgA pemphigus | Cultured skin |
| Paraneoplastic pemphigus | Rat bladder |
See also[edit]
- List of cutaneous conditions
- List of genes mutated in cutaneous conditions
- List of cutaneous conditions caused by mutations in keratins
References[edit]
- Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0.
- James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.