DNA-3-methyladenine glycosylase II
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| DNA-3-methyladenine glycosylase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.2.21 | ||||||||
| CAS no. | 89287-38-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
DNA-3-methyladenine glycosylase II (EC 3.2.2.21) is an enzyme[1][2][3][4] that catalyses the following chemical reaction:
- Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine
Involved in the removal of alkylated bases from DNA in Escherichia coli.
Evolution[edit]
Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria Pfam PF06029. The second, methylpurine-DNA glycosylase (MPG) Pfam PF02245 is found in vertebrates including humans.[5]
Nomenclature[edit]
DNA-3-methyladenine glycosylase II is also known as
- deoxyribonucleate 3-methyladenine glycosides II
- 3-methyladenine DNA glycosylase II
- DNA-3-methyladenine glycosides II
- AlkA
- alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
See also[edit]
- MAG1 (DNA-3-methyladenine glycosylase)
References[edit]
- ^ Evensen G, Seeberg E (April 1982). "Adaptation to alkylation resistance involves the induction of a DNA glycosylase". Nature. 296 (5859): 773–775. Bibcode:1982Natur.296..773E. doi:10.1038/296773a0. PMID 7040984. S2CID 4318955.
- ^ Karran P, Hjelmgren T, Lindahl T (April 1982). "Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents". Nature. 296 (5859): 770–773. Bibcode:1982Natur.296..770K. doi:10.1038/296770a0. PMID 7040983. S2CID 4367726.
- ^ Riazuddin S, Lindahl T (May 1978). "Properties of 3-methyladenine-DNA glycosylase from Escherichia coli". Biochemistry. 17 (11): 2110–2118. doi:10.1021/bi00604a014. PMID 352392.
- ^ Thomas L, Yang CH, Goldthwait DA (March 1982). "Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine". Biochemistry. 21 (6): 1162–1169. doi:10.1021/bi00535a009. PMID 7041972.
- ^ Krokan HE, Bjørås M (April 2013). "Base excision repair". Cold Spring Harbor Perspectives in Biology. 5 (4): a012583. doi:10.1101/cshperspect.a012583. PMC 3683898. PMID 23545420.
External links[edit]
- DNA-3-methyladenine+glycosylase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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