Protein-coding gene in the species Homo sapiens
DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene .[5] [6] [7]
The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae . The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3 , mouse Dj3 and rat Dj2 gene products.[7]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000069345 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031701 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA" . Mol Cell Biol . 18 (9): 5546–56. doi :10.1128/MCB.18.9.5546 . PMC 109139 PMID 9710638 . ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature" . Cell Stress & Chaperones . 5 (2): 98–112. doi :10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-06). ISSN 1466-1268 . PMC 312896 PMID 11147971 . {{cite journal }}: CS1 maint: DOI inactive as of March 2024 (link )^ a b "Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2" . Further reading [ edit ] Bonwaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Edwards MC, Liegeois N, Horecka J, et al. (1998). "Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells" . Genetics . 147 (3): 1063–76. doi :10.1093/genetics/147.3.1063 . PMC 1208234 PMID 9383053 . Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer . 83 (4): 456–64. doi :10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID 10508479 . S2CID 21839750 . Diefenbach J, Kindl H (2000). "The membrane-bound DnaJ protein located at the cytosolic site of glyoxysomes specifically binds the cytosolic isoform 1 of Hsp70 but not other Hsp70 species" . Eur. J. Biochem . 267 (3): 746–54. doi :10.1046/j.1432-1327.2000.01053.x PMID 10651811 . Terada K, Mori M (2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70" . J. Biol. Chem . 275 (32): 24728–34. doi :10.1074/jbc.M002021200 PMID 10816573 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Willingham S, Outeiro TF, DeVit MJ, et al. (2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science . 302 (5651): 1769–72. Bibcode :2003Sci...302.1769W . doi :10.1126/science.1090389 . PMID 14657499 . S2CID 43221047 . Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (34): 12479–84. Bibcode :2004PNAS..10112479K . doi :10.1073/pnas.0403413101 PMC 515085 PMID 15308774 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . External links [ edit ]
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