Protein-coding gene in the species Homo sapiens
ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene .[5] [6] [7]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ (October 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation" . The EMBO Journal . 14 (19): 4781–93. doi :10.1002/j.1460-2075.1995.tb00160.x . PMC 394576 PMID 7588608 . ^ de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (June 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics . 42 (2): 227–35. doi :10.1006/geno.1997.4730 . PMID 9192842 . ^ "Entrez Gene: ERF Ets2 repressor factor" . Further reading [ edit ] Liu D, Pavlopoulos E, Modi W, Moschonas N, Mavrothalassitis G (March 1997). "ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes" . Oncogene . 14 (12): 1445–51. doi :10.1038/sj.onc.1200965 PMID 9136988 . Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G (June 1999). "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation" . Molecular and Cellular Biology . 19 (6): 4121–33. doi :10.1128/mcb.19.6.4121 . PMC 104371 PMID 10330152 . Dintilhac A, Bernués J (March 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences" . The Journal of Biological Chemistry . 277 (9): 7021–8. doi :10.1074/jbc.M108417200 hdl :10261/112516 PMID 11748221 . Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners" . FEBS Letters . 517 (1–3): 167–71. doi :10.1016/S0014-5793(02)02614-5 PMID 12062430 . S2CID 84792445 . Bain M, Mendelson M, Sinclair J (January 2003). "Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells" . The Journal of General Virology . 84 (Pt 1): 41–9. doi :10.1099/vir.0.18633-0 PMID 12533699 . Xiao X, Athanasiou M, Sidorov IA, Horikawa I, Cremona G, Blair D, Barret JC, Dimitrov DS (December 2003). "Role of Ets/Id proteins for telomerase regulation in human cancer cells". Experimental and Molecular Pathology . 75 (3): 238–47. doi :10.1016/S0014-4800(03)00092-3 . PMID 14611815 . Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ (December 2003). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis". Neurobiology of Disease . 14 (3): 349–56. doi :10.1016/S0969-9961(03)00107-4 . PMID 14678752 . S2CID 30142532 . Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G (February 2004). "ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression" . Molecular and Cellular Biology . 24 (3): 1206–18. doi :10.1128/MCB.24.3.1206-1218.2004 . PMC 321421 PMID 14729966 . Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS" . Cell Cycle . 6 (13): 1594–604. doi :10.4161/cc.6.13.4336 PMID 17525531 . Verykokakis M, Papadaki C, Vorgia E, Le Gallic L, Mavrothalassitis G (October 2007). "The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression" . The Journal of Biological Chemistry . 282 (41): 30285–94. doi :10.1074/jbc.M704428200 PMID 17699159 . External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
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