Gentamicin 3'-N-acetyltransferase

In enzymology, a gentamicin 3'-N-acetyltransferase (EC 2.3.1.60) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + gentamicin C ${\displaystyle \rightleftharpoons }$ CoA + N₃'-acetylgentamicin C

Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C, whereas its two products are CoA and N3'-acetylgentamicin C.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C N3'-acetyltransferase. Other names in common use include gentamicin acetyltransferase I, aminoglycoside acetyltransferase AAC(3)-1, gentamicin 3'-N-acetyltransferase, and acetyl-CoA:gentamicin-C N3'-acetyltransferase.

References[edit]

• Angelatou F, Litsas SB, Kontomichalou P (February 1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot. 35 (2): 235–44. doi:10.7164/antibiotics.35.235. PMID 6281224.
• Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ (1976). "Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate". Antimicrob. Agents Chemother. 9 (6): 951–5. doi:10.1128/aac.9.6.951. PMC 429656. PMID 820250.
• Williams JW, Northrop DB (1976). "Purification and properties of gentamicin acetyltransferase I". Biochemistry. 15 (1): 125–31. doi:10.1021/bi00646a019. PMID 764855.