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Virus classification Edit this classification
(unranked): Virus
Family: Globuloviridae
  • Alphaglobulovirus
Negative-contrast electron micrographs of virions of Pyrobaculum spherical virus (PSV, genus Alphaglobulovirus). (Left) Intact virions; arrows indicate spherical protrusions. (Right) Partially disrupted virions extruding disordered nucleoprotein core. The bars represent 100 nm. Modified from (Häring et al., 2004; provided by ICTV).

Globuloviridae is a family of hyperthermophilic archaeal viruses. Crenarchaea of the genera Pyrobaculum and Thermoproteus (both in Thermoproteaceae) serve as natural hosts. There are four species in this family, assigned to a single genus, Alphaglobulovirus.[1][2][3]


The family contains one genus which contains four species:[3]


Virions in the Globuloviridae are spherical and enveloped. The diameter is around 100 nm.[1][2]

Genome organization of Pyrobaculum spherical virus (PSV) showing location, sizes and direction of putative genes.

Genomes are linear dsDNA and non-segmented, around 20–30kb in length.[1][2]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Alphaglobulovirus Spherical Enveloped Linear Monopartite

Life cycle[edit]

Viral replication is cytoplasmic. DNA-templated transcription is the method of transcription. Pyrobaculum and Thermoproteus archaea serve as the natural host. Transmission routes are passive diffusion.[1]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Alphaglobulovirus Pyrobaculum and Thermoproteus archaea None Injection Budding Cytoplasm Cytoplasm Passive diffusion


  1. ^ a b c d Prangishvili, D; Krupovic, M; ICTV Report Consortium (2018). "ICTV Virus Taxonomy Profile: Globuloviridae". The Journal of General Virology. 99 (10): 1357–1358. doi:10.1099/jgv.0.001123. PMID 30091697.
  2. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ^ a b "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 24 May 2021.
  • Häring M, Peng X, Brügger K, Rachel R, Stetter KO, Garrett RA, Prangishvili D (2004). "Morphology and genome organization of the virus PSV of the hyperthermophilic archaeal genera Pyrobaculum and Thermoproteus: a novel virus family, the Globuloviridae". Virology. 323 (2): 233–242. doi:10.1016/j.virol.2004.03.002. PMID 15193919.

External links[edit]