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Glomerulopathy is diseases that impact the glomeruli in the nephron, either inflammatory or noninflammatory.[1] Glomerulopathy includes collapsing glomerulopathy, glomerulocystic kidney disease, glomerulomegaly, membranous nephropathy, and tip lesion glomerulopathy.[2]

Collapsing glomerulopathy (CG) is a clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus.[3]

Glomerulocystic kidney disease is a rare form of renal cyst disease. Cortical microcysts, which are portrayed by cystic dilatation of Bowman's spaces, are its defining feature.[4]

Glomerulomegaly is defined by unusually large glomeruli.[5]

Membranous nephropathy (MN) is an uncommon autoimmune condition in which autoantibodies directed primarily against podocyte antigens target the glomerulus, causing electron-dense immune complexes to form, complement activation to occur, and severe proteinuria.[6]

The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic nephrotic syndrome patients.[7]

See also[edit]


  1. ^ "Monarch Initiative". Retrieved January 7, 2024.
  2. ^ "Glomerulopathy (Concept Id: C0268731)". NCBI. October 31, 2023. Retrieved January 7, 2024.
  3. ^ Cutrim, Érico Murilo Monteiro; Neves, Precil Diego Miranda de Meneses; Campos, Marcos Adriano Garcia; Wanderley, Davi Campos; Teixeira-Júnior, Antonio Augusto Lima; Muniz, Monique Pereira Rêgo; Ladchumananandasivam, Francisco Rasiah; Gomes, Orlando Vieira; Vasco, Rafael Fernandes Vanderlei; Brito, Dyego José de Araújo; Lages, Joyce Santos; Salgado-Filho, Natalino; Guedes, Felipe Leite; de Almeida, José Bruno; Magalhães, Marcelo; Araújo, Stanley de Almeida; Silva, Gyl Eanes Barros (March 3, 2022). "Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium". Frontiers in Medicine. 9. Frontiers Media SA. doi:10.3389/fmed.2022.846173. ISSN 2296-858X. PMC 8927620. PMID 35308512.
  4. ^ Sahay, M.; Gowrishankar, S. (April 13, 2010). "Glomerulocystic disease". Clinical Kidney Journal. 3 (4). Oxford University Press (OUP): 349–350. doi:10.1093/ndtplus/sfq048. ISSN 2048-8505. PMID 25949428.
  5. ^ Hughson, M. D.; Hoy, W. E.; Douglas-Denton, R. N.; Zimanyi, M. A.; Bertram, J. F. (November 29, 2010). "Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations". Nephrology Dialysis Transplantation. 26 (7). Oxford University Press (OUP): 2202–2208. doi:10.1093/ndt/gfq688. ISSN 0931-0509. PMC 3164445. PMID 21115671.
  6. ^ Ronco, Pierre; Plaisier, Emmanuelle; Debiec, Hanna (February 5, 2021). "Advances in Membranous Nephropathy". Journal of Clinical Medicine. 10 (4). MDPI AG: 607. doi:10.3390/jcm10040607. ISSN 2077-0383.
  7. ^ Stokes, M. Barry; Markowitz, Glen S.; Lin, Julie; Valeri, Anthony M.; D'Agati, Vivette D. (2004). "Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum". Kidney International. 65 (5). Elsevier BV: 1690–1702. doi:10.1111/j.1523-1755.2004.00563.x. ISSN 0085-2538. PMID 15086908.

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