List of EC numbers (EC 3)

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This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 3.1: Acting on Ester Bonds[edit]

EC 3.1.1: Carboxylic Ester Hydrolases[edit]

(*) No Wikipedia article

EC 3.1.2: Thioester Hydrolases[edit]

EC 3.1.3: Phosphoric Monoester Hydrolases[edit]

EC 3.1.4: Phosphoric Diester Hydrolases[edit]

(*) No Wikipedia article

EC 3.1.5: Triphosphoric Monoester Hydrolases[edit]

EC 3.1.6: Sulfuric Ester Hydrolases[edit]

(*) No Wikipedia article

EC 3.1.7: Diphosphoric Monoester Hydrolases[edit]

(*) No Wikipedia article

EC 3.1.8: Phosphoric Triester Hydrolases[edit]

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters[edit]

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[edit]

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[edit]

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters[edit]

(*) No Wikipedia article

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters[edit]

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5[edit]

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases[edit]

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters[edit]

  • EC 3.1.27.1: Now EC 4.6.1.19, ribonuclease T2, since the primary reaction is that of a lyase
  • EC 3.1.27.2: Now EC 4.6.1.22, Bacillus subtilis ribonuclease, since the reaction catalysed is that of a lyase
  • EC 3.1.27.3: Now EC 4.6.1.24, ribonuclease T1, since the primary reaction is that of a lyase
  • EC 3.1.27.4: Now EC 4.6.1.20, ribonuclease U2, since the primary reaction is that of a lyase
  • EC 3.1.27.5: Now EC 4.6.1.18, pancreatic ribonuclease.
  • EC 3.1.27.6: Now EC 4.6.1.21, Enterobacter ribonuclease, since the primary reaction is that of a lyase
  • EC 3.1.27.7: ribonuclease F
  • EC 3.1.27.8: ribonuclease V
  • EC 3.1.27.9: Now EC 4.6.1.16, tRNA-intron lyase
  • EC 3.1.27.10: Now EC 4.6.1.23, ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[edit]

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[edit]

EC 3.2: Glycosylases[edit]

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds[edit]

(*) No Wikipedia article

EC 3.2.2: Hydrolysing N-Glycosyl Compounds[edit]

(*) No Wikipedia article

EC 3.2.3: Hydrolysing S-Glycosyl Compounds[edit]

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds[edit]

EC 3.3.1: Thioether and trialkylsulfonium hydrolases[edit]

EC 3.3.2: Ether Hydrolases[edit]

(*) No Wikipedia article

EC 3.4: Acting on peptide bondsPeptidase[edit]

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)[edit]

  • EC 3.4.1.1: Now EC 3.4.11.1, leucyl aminopeptidase
  • EC 3.4.1.2: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.1.3: Now EC 3.4.11.4, tripeptide aminopeptidase
  • EC 3.4.1.4: Now EC 3.4.11.5, prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)[edit]

  • EC 3.4.2.1: Now EC 3.4.17.1, carboxypeptidase A
  • EC 3.4.2.2: Now EC 3.4.17.2, carboxypeptidase B
  • EC 3.4.2.3: Now EC 3.4.17.4, Gly-Xaa carboxypeptidase

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)[edit]

  • EC 3.4.3.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.3: Now EC 3.4.13.3, Xaa-His dipeptidase
  • EC 3.4.3.4: Now EC 3.4.13.5, Xaa-methyl-His dipeptidase
  • EC 3.4.3.5: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.3.6: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.7: Now EC 3.4.13.9, Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)[edit]

  • EC 3.4.4.1: Now EC 3.4.23.1, pepsin A
  • EC 3.4.4.2: Now EC 3.4.23.2, pepsin B
  • EC 3.4.4.3: Now EC 3.4.23.4, chymosin
  • EC 3.4.4.4: Now EC 3.4.21.4, trypsin
  • EC 3.4.4.5: Now EC 3.4.21.1, chymotrypsin
  • EC 3.4.4.6: Now EC 3.4.21.1, chymotrypsin
  • EC 3.4.4.7: Now covered by EC 3.4.21.36, pancreatic elastase and EC 3.4.21.37, leukocyte elastase
  • EC 3.4.4.8: Now EC 3.4.21.9, enteropeptidase
  • EC 3.4.4.9: Now EC 3.4.14.1, dipeptidyl-peptidase I
  • EC 3.4.4.10: Now EC 3.4.22.2, papain
  • EC 3.4.4.11: Now EC 3.4.22.6, chymopapain
  • EC 3.4.4.12: Now EC 3.4.22.3, ficain
  • EC 3.4.4.13: Now EC 3.4.21.5, thrombin
  • EC 3.4.4.14: Now EC 3.4.21.7, plasmin
  • EC 3.4.4.15: Now EC 3.4.23.15, renin
  • EC 3.4.4.16: Now covered by the microbial serine proteinases EC 3.4.21.62 (subtilisin), EC 3.4.21.63 (oryzin), EC 3.4.21.64 (endopeptidase K), EC 3.4.21.65 (thermomycolin), EC 3.4.21.66 (thermitase) and EC 3.4.21.67 (ndopeptidase So)
  • EC 3.4.4.17: Now covered by the microbial aspartic proteinases EC 3.4.23.20 (penicillopepsin), EC 3.4.23.21 (rhizopuspepsin), EC 3.4.23.22 (endothiapepsin), EC 3.4.23.23 (mucorpepsin), EC 3.4.23.24 (candidapepsin), EC 3.4.23.25 (saccharopepsin), EC 3.4.23.26 (rhodotorulapepsin), EC 3.4.21.103 (physarolisin), EC 3.4.23.28 (acrocylindropepsin), EC 3.4.23.29 (polyporopepsin) and EC 3.4.23.30 (pycnoporopepsin)
  • EC 3.4.4.18: Now EC 3.4.22.10, streptopain
  • EC 3.4.4.19: Now EC 3.4.24.3, microbial collagenase
  • EC 3.4.4.20: Now EC 3.4.22.8, clostripain
  • EC 3.4.4.21: Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein)
  • EC 3.4.4.22: now EC 3.4.23.3, gastricsin
  • EC 3.4.4.23: now EC 3.4.23.5, cathepsin D
  • EC 3.4.4.24: now covered by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain)
  • EC 3.4.4.25: deleted

EC 3.4.11 Aminopeptidases[edit]

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)[edit]

  • EC 3.4.12.1: now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.2: now EC 3.4.17.1, carboxypeptidase A
  • EC 3.4.12.3: now EC 3.4.17.2, carboxypeptidase B
  • EC 3.4.12.4: now EC 3.4.16.2, lysosomal Pro-Xaa carboxypeptidase
  • EC 3.4.12.5: now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
  • EC 3.4.12.6: now EC 3.4.17.8, muramoyl-pentapeptidase carboxypeptidase
  • EC 3.4.12.7: now EC 3.4.17.3, lysine carboxypeptidase
  • EC 3.4.12.8: now EC 3.4.17.4, Gly-Xaa carboxypeptidase
  • EC 3.4.12.9: aspartate carboxypeptidase
  • EC 3.4.12.10: now EC 3.4.19.9, γ-glutamyl hydrolase
  • EC 3.4.12.11: now EC 3.4.17.6, alanine carboxypeptidase
  • EC 3.4.12.12: now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases[edit]

(*) No Wikipedia article

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases[edit]

(*) No Wikipedia article

EC 3.4.15 Peptidyl dipeptidases[edit]

EC 3.4.16 Serine type carboxypeptidases[edit]

EC 3.4.17 Metallocarboxypeptidases[edit]

(*) No Wikipedia article

EC 3.4.18 Cysteine type carboxypeptidases[edit]

EC 3.4.19 Omega peptidases[edit]

(*) No Wikipedia article

EC 3.4.21: Serine proteases[edit]

(*) No Wikipedia article

EC 3.4.22 Cysteine proteases[edit]

EC 3.4.23 Aspartic endopeptidases[edit]

EC 3.4.24: Metallopeptidases[edit]

EC 3.4.25 Threonine endopeptidases[edit]

EC 3.4.99 Endopeptidases of unknown catalytic mechanism[edit]

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds[edit]

3.5.1: In linear amides[edit]

(*) No Wikipedia article

3.5.2: In cyclic amides[edit]

(*) No Wikipedia article

3.5.3: In linear amidines[edit]

(*) No Wikipedia article

3.5.4: In cyclic amidines[edit]

(*) No Wikipedia article

3.5.5: In nitriles[edit]

3.5.99: In other compounds[edit]

(*) No Wikipedia article

EC 3.6: Acting on acid anhydrides[edit]

3.6.1: In phosphorus-containing anhydrides[edit]

(*) No Wikipedia article

3.6.2: In sulfonyl-containing anhydrides[edit]

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances[edit]

  • EC 3.6.3.1: phospholipid-translocating ATPase
  • EC 3.6.3.2: Now EC 7.2.2.14, P-type Mg2+ transporter
  • EC 3.6.3.3: Now EC 7.2.2.21, Cd2+-exporting ATPase
  • EC 3.6.3.4: Now EC 7.2.2.9, Cu2+-exporting ATPase
  • EC 3.6.3.5: Now EC 7.2.2.12, Zn2+-exporting ATPase
  • EC 3.6.3.6: Now EC 7.1.2.1, P-type H+-exporting transporter
  • EC 3.6.3.7: Now EC 7.2.2.3, P-type Na+ transporter
  • EC 3.6.3.8: Now EC 7.2.2.10, Ca2+-transporting ATPase
  • EC 3.6.3.9: Now EC 7.2.2.13, Na+/K+-exchanging ATPase
  • EC 3.6.3.10: Now EC 7.2.2.19, H+/K+-exchanging ATPase
  • EC 3.6.3.11: Cl-transporting ATPase. The activity was only ever studied in crude extracts, and is an artifact
  • EC 3.6.3.12: Now EC 7.2.2.6, K+-transporting ATPase
  • EC 3.6.3.13:Identical to EC 3.6.3.1, phospholipid-translocating ATPase
  • EC 3.6.3.14: Now EC 7.1.2.2, H+-transporting two-sector ATPase
  • EC 3.6.3.15: Now EC 7.2.2.1, Na+-transporting two-sector ATPase
  • EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase
  • EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2
  • EC 3.6.3.18: Now EC 7.5.2.2, ABC-type oligosaccharide transporter
  • EC 3.6.3.19: Now EC 7.5.2.1, ABC-type maltose transporter
  • EC 3.6.3.20: Now EC 7.6.2.10, glycerol-3-phosphate-transporting ATPase
  • EC 3.6.3.21: Now EC 7.4.2.1, ABC-type polar-amino-acid transporter
  • EC 3.6.3.22: Now EC 7.4.2.2, ABC-type nonpolar-amino-acid transporter
  • EC 3.6.3.23: Now EC 7.4.2.6, oligopeptide-transporting ATPase
  • EC 3.6.3.24: Now EC 7.2.2.11, nickel-transporting ATPase
  • EC 3.6.3.25: Now EC 7.3.2.3, sulfate-transporting ATPase
  • EC 3.6.3.26: Now EC 7.3.2.4, nitrate-transporting ATPase
  • EC 3.6.3.27: Now EC 7.3.2.1, ABC-type phosphate transporter
  • EC 3.6.3.28: Now EC 7.3.2.2, ABC-type phosphonate transporter
  • EC 3.6.3.29: Now EC 7.3.2.5, molybdate-transporting ATPase
  • EC 3.6.3.30: Now EC 7.2.2.7, Fe3+-transporting ATPase
  • EC 3.6.3.31: Now EC 7.6.2.11, polyamine-transporting ATPase
  • EC 3.6.3.32: Now EC 7.6.2.9, quaternary-amine-transporting ATPase
  • EC 3.6.3.33: Now EC 7.6.2.8, vitamin B12-transporting ATPase
  • EC 3.6.3.34: now recognized to be at least three separate enzymes EC 7.2.2.16, iron(III) hydroxamate ABC transporter, EC 7.2.2.17, ferric enterobactin ABC transporter, and EC 7.2.2.18, ferric citrate ABC transporter
  • EC 3.6.3.35: Now EC 7.2.2.5, manganese-transporting ATPase
  • EC 3.6.3.36: Now EC 7.6.2.7, taurine-transporting ATPase
  • EC 3.6.3.37: Now EC 7.6.2.6, guanine-transporting ATPase
  • EC 3.6.3.38: Now EC 7.6.2.12, ABC-type capsular-polysaccharide transporter
  • EC 3.6.3.39: Now EC 7.5.2.5, lipopolysaccharide-transporting ATPase
  • EC 3.6.3.40: Now EC 7.5.2.4, teichoic-acid-transporting ATPase
  • EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase
  • EC 3.6.3.42: Now EC 7.5.2.3, β-glucan-transporting ATPase
  • EC 3.6.3.43: Now EC 7.4.2.5, peptide-transporting ATPase
  • EC 3.6.3.44: Now EC 7.6.2.2, ABC-type xenobiotic transporter
  • EC 3.6.3.45: Now included with EC 3.6.3.44, xenobiotic-transporting ATPase
  • EC 3.6.3.46: Now EC 7.2.2.2, ABC-type Cd2+ transporter
  • EC 3.6.3.47: Now EC 7.6.2.4, fatty-acyl-CoA-transporting ATPase
  • EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase
  • EC 3.6.3.49: Now EC 5.6.1.6, channel-conductance-controlling ATPase
  • EC 3.6.3.50: Now EC 7.4.2.8, protein-secreting ATPase
  • EC 3.6.3.51: Now EC 7.4.2.3, mitochondrial protein-transporting ATPase
  • EC 3.6.3.52: Now EC 7.4.2.4, chloroplast protein-transporting ATPase
  • EC 3.6.3.53: Now EC 7.2.2.15, Ag+-exporting ATPase
  • EC 3.6.3.54: Now EC 7.2.2.8, Cu+-exporting ATPase
  • EC 3.6.3.55: Now EC 7.3.2.6, tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement[edit]

  • EC 3.6.4.1: Now EC 5.6.1.8, myosin ATPase
  • EC 3.6.4.2: Now EC 5.6.1.2, dynein ATPase
  • EC 3.6.4.3: Now EC 5.6.1.1, microtubule-severing ATPase
  • EC 3.6.4.4: Now EC 5.6.1.3, plus-end-directed kinesin ATPase
  • EC 3.6.4.5: Now EC 5.6.1.4, minus-end-directed kinesin ATPase
  • EC 3.6.4.6: vesicle-fusing ATPase
  • EC 3.6.4.7: peroxisome-assembly ATPase
  • EC 3.6.4.8: Now EC 5.6.1.5, proteasome ATPase
  • EC 3.6.4.9: Now EC 5.6.1.7, chaperonin ATPase
  • EC 3.6.4.10: non-chaperonin molecular chaperone ATPase
  • EC 3.6.4.11: Deleted, the activity has been shown not to take place
  • EC 3.6.4.12: DNA helicase
  • EC 3.6.4.13: RNA helicase

3.6.5: Acting on GTP to facilitate cellular and subcellular movement[edit]

EC 3.7: Acting on carbon-carbon bonds[edit]

EC 3.7.1: In ketonic substances[edit]

(*) No Wikipedia article

EC 3.8: Acting on halide bonds[edit]

EC 3.8.1: Acting on halide bonds[edit]

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)[edit]

  • EC 3.8.2.1: Now EC 3.1.8.2, diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds[edit]

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)[edit]

  • EC 3.9.1.1: phosphoamidase
  • EC 3.9.1.2: protein arginine phosphatase (*)
  • EC 3.9.1.3: phosphohistidine phosphatase (*)
(*) No Wikipedia article

EC 3.10: Acting on sulfur-nitrogen bonds[edit]

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)[edit]

EC 3.11: Acting on carbon-phosphorus bonds[edit]

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)[edit]

EC 3.12: Acting on sulfur-sulfur bonds[edit]

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)[edit]

EC 3.13: Acting on carbon-sulfur bonds[edit]

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)[edit]

(*) No Wikipedia article

References[edit]

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37: D593–D597. doi:10.1093/nar/gkn582.