m7G(5')pppN diphosphatase
From Wikipedia the free encyclopedia
| m7G(5')pppN diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.30 | ||||||||
| CAS no. | 82599-75-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a m7G(5')pppN diphosphatase (EC 3.6.1.30) is an enzyme that catalyzes the chemical reaction
- 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O 7-methylguanosine 5'-phosphate + polynucleotide
Thus, the two substrates of this enzyme are 7-methylguanosine 5'-triphospho-5'-polynucleotide and H2O, whereas its two products are 7-methylguanosine 5'-phosphate and polynucleotide.
This is the enzyme involved in the processing of amphetamines of the cathinone group, including mephedrone and khat.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase. Other names in common use include decapase, and m7G(5')pppN pyrophosphatase.
See also[edit]
References[edit]
- Lavers GC (1977). "Cleavage of pm7G from mRNA 5' terminal cap structures by pyrophosphatase activity in embryonic chick lens cells". Mol. Biol. Rep. 3 (6): 413–20. doi:10.1007/BF00808382. PMID 593271.
- Nuss DL, Altschuler RE, Peterson AJ (1982). "Purification and characterization of the m7G(5')pppN-pyrophosphatase from human placenta". J. Biol. Chem. 257 (11): 6224–30. PMID 6122684.
- Nuss DL, Furuichi Y (1977). "Characterization of the m7G(5')pppN-pyrophosphatase activity from HeLa cells". J. Biol. Chem. 252 (9): 2815–21. PMID 16003.
