MRPS2

MRPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36
External IDs	OMIM: 611971 MGI: 2153089 HomoloGene: 99837 GeneCards: MRPS2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 135,499,965 bp[1] End 135,505,141 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,358,078 bp[2] End 28,361,190 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right lobe of liver left adrenal gland right uterine tube gastrocnemius muscle left ventricle body of stomach body of pancreas skin of abdomen stromal cell of endometrium Top expressed in primitive streak abdominal wall maxillary prominence endocardial cushion proximal tubule ureter facial motor nucleus hair follicle brown adipose tissue left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component small ribosomal subunit ribosome intracellular anatomical structure mitochondrion mitochondrial inner membrane mitochondrial small ribosomal subunit Biological process protein biosynthesis mitochondrial translation mitochondrial translational elongation mitochondrial translational termination mitochondrial ribosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51116 118451 Ensembl ENSG00000122140 ENSMUSG00000035772 UniProt Q9Y399 Q924T2 RefSeq (mRNA) NM_016034 NM_001371401 NM_001166031 NM_080452 RefSeq (protein) NP_057118 NP_001358330 NP_001159503 NP_536700 Location (UCSC) Chr 9: 135.5 – 135.51 Mb Chr 2: 28.36 – 28.36 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. ^[5]

Function[edit]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

See also[edit]

• Mitochondrial ribosome

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.