Mitiglinide

Mitiglinide

Clinical data
Trade names	Glufast
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (tablets)
ATC code	A10BX08 (WHO)
Identifiers
IUPAC name (−)-(2S,3a,7a-cis)-α-Benzylhexahydro-γ-oxo-2-isoindolinebutyric acid
CAS Number	145375-43-5 N
PubChem CID	121891
DrugBank	DB01252 Y
ChemSpider	108739 Y
UNII	D86I0XLB13
KEGG	D01854 Y
ChEMBL	ChEMBL471498 Y
CompTox Dashboard (EPA)	DTXSID4048303
Chemical and physical data
Formula	C19H25NO3
Molar mass	315.413 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)[C@@H](Cc1ccccc1)CC(=O)N3C[C@H]2CCCC[C@H]2C3
InChI InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m0/s1 Y Key:WPGGHFDDFPHPOB-BBWFWOEESA-N Y
NY (what is this?)  (verify)

Mitiglinide (INN,^[1] trade name Glufast) is a drug for the treatment of type 2 diabetes.^[2]

Mitiglinide belongs to the meglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. Mitiglinide has not yet gained FDA approval.

Pharmacology[edit]

Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive potassium K_ATP channels in pancreatic β cells.

Dosage[edit]

Mitiglinide is delivered in tablet form.

References[edit]

External links[edit]

• Elixir Pharmaceuticals — website of the U.S. rights holder for mitiglinide.