Mitochondrial ribosomal protein L13

MRPL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDs	OMIM: 610200 MGI: 2137218 HomoloGene: 90894 GeneCards: MRPL13
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 120,380,761 bp[1] End 120,445,402 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 55,397,490 bp[2] End 55,421,144 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right adrenal gland islet of Langerhans rectum stromal cell of endometrium left adrenal gland Achilles tendon left ventricle right ventricle right lobe of liver Top expressed in medial ganglionic eminence maxillary prominence intercostal muscle external carotid artery internal carotid artery right ventricle digastric muscle vas deferens facial motor nucleus Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis negative regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28998 68537 Ensembl ENSG00000172172 ENSMUSG00000022370 UniProt Q9BYD1 Q9D1P0 RefSeq (mRNA) NM_014078 NM_026759 RefSeq (protein) NP_054797 NP_081035 Location (UCSC) Chr 8: 120.38 – 120.45 Mb Chr 15: 55.4 – 55.42 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. ^[5]

Function[edit]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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