Murid gammaherpesvirus 4

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Murid gammaherpesvirus 4
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Genus: Rhadinovirus
Murid gammaherpesvirus 4

Murid gammaherpesvirus 4 (MuHV-4) is a species of virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae. This species infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.[1] Murid gammaherpesvirus 4 currently serves as a model for study of human gammaherpesvirus pathogenesis.[2]


Seven strains of Murid gammaherpesvirus 4 have been isolated, including the following six:

  • MuHV-Šum
  • MuHV-60
  • MuHV-68
  • MuHV-72
  • MuHV-76
  • MuHV-4556


  1. ^ Jela Mistríková & Július Rajčáni (2008). "Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome". Central European Journal of Biology. 3 (1 / March, 2008). doi:10.2478/s11535-008-0002-0.
  2. ^ Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M (2006). "Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains". Virus Genes. 33 (1): 51–8. doi:10.1007/s11262-005-0038-4. PMID 16791419. S2CID 25195454.