Oviductin
From Wikipedia the free encyclopedia
| Oviductin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.120 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Oviductin (EC 3.4.21.120, oviductal protease) is an enzyme found in the Japanese toad (Bufo japonicus) and in the African clawed frog (Xenopus laevis).[1][2][3] Ovulated coelomic egg cells are not fertilisable in these species until they pass through the oviduct, where Oviductin is located.[4] Oviductin catalyses the following chemical reaction in Xenopus laevis:
- Preferential cleavage at Gly-Ser-Arg373- of glycoprotein gp43 in the coelemic egg envelope to yield gp41.
References[edit]
- ^ Hardy DM, Hedrick JL (May 1992). "Oviductin. Purification and properties of the oviductal protease that processes the molecular weight 43,000 glycoprotein of the Xenopus laevis egg envelope". Biochemistry. 31 (18): 4466–72. doi:10.1021/bi00133a012. PMID 1581303.
- ^ Lindsay LL, Wieduwilt MJ, Hedrick JL (April 1999). "Oviductin, the Xenopus laevis oviductal protease that processes egg envelope glycoprotein gp43, increases sperm binding to envelopes, and is translated as part of an unusual mosaic protein composed of two protease and several CUB domains". Biology of Reproduction. 60 (4): 989–95. doi:10.1095/biolreprod60.4.989. PMID 10084976.
- ^ Hiyoshi M, Takamune K, Mita K, Kubo H, Sugimoto Y, Katagiri C (March 2002). "Oviductin, the oviductal protease that mediates gamete interaction by affecting the vitelline coat in Bufo japonicus: its molecular cloning and analyses of expression and posttranslational activation". Developmental Biology. 243 (1): 176–84. doi:10.1006/dbio.2001.0558. PMID 11846486.
- ^ Hiyoshi, Masateru; Takamune, Kazufumi; Mita, Koichi; Kubo, Hideo; Sugimoto, Yasusi; Katagiri, Chiaki (March 2002). "Oviductin, the Oviductal Protease That Mediates Gamete Interaction by Affecting the Vitelline Coat in Bufo japonicus: Its Molecular Cloning and Analyses of Expression and Posttranslational Activation". Developmental Biology. 243 (1): 176–184. doi:10.1006/dbio.2001.0558. PMID 11846486.
External links[edit]
- Oviductin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
