PRB1

PRB1
Identifiers
Aliases	PRB1, PM, PMF, PMS, PRB1L, PRB1M, proline rich protein BstNI subfamily 1, proline rich protein BstNI subfamily 1 (gene/pseudogene)
External IDs	OMIM: 180989 GeneCards: PRB1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,355,591 bp
RNA expression pattern
	Top expressed in
	thymus; ; bone marrow; ; sural nerve; ; bone marrow cells; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; superior frontal gyrus; ; skin of abdomen; ; hippocampus proper;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	extracellular region;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	5542
	n/a
	ENSG00000251655
	n/a
	P04280
	n/a
	NM_199354; NM_005039; NM_199353; NM_001367912
	n/a
	NP_005030; NP_001354841
	n/a
	Wikidata
View/Edit Human

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.^[3]^[4]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[4]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000251655 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219. PMID 8317492.
^ ^a ^b "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".

Further reading[edit]

Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850. {{cite book}}: |journal= ignored (help)
Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science. 197 (4301): 378–9. Bibcode:1977Sci...197..378I. doi:10.1126/science.877561. PMID 877561.
Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. doi:10.1016/S0021-9258(18)42385-X. PMID 1618808.
Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID 3521730.
Azen E, Lyons KM, McGonigal T, et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. Bibcode:1984PNAS...81.5561A. doi:10.1073/pnas.81.17.5561. PMC 391746. PMID 6089212.
Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. doi:10.1093/oxfordjournals.jbchem.a134553. PMID 6671974.
Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry. 21 (25): 6558–62. doi:10.1021/bi00268a036. PMID 6924859.
Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. doi:10.1093/oxfordjournals.jbchem.a133900. PMID 7118863.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000251655 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8317492-3] Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219. PMID 8317492.

[entrez-4] "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".

[1]

[2]

[3]

[4]

PRB1

References[edit]

Further reading[edit]

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